CAS: 124436-59-5; Ethyl 4-(2-(1-(6-Methylpyridazin-3-yl)Piperidin-4-yl)Ethoxy)Benzoate

上下游产品

Ethyl 4-hydroxybenzoate 3-methyl-6-[4-(2-chloroethyl)-1-piperidynyl]pyridazine

📜过氧化氢酶,3-[4-(2-氯乙基)-1-哌啶基]-6-甲基哒嗪置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应生成吡罗达韦
参考文献:An Orally Bioavailable Oxime Ether Capsid Binder With Potent Activity Against Human Rhinovirus
标题:An Orally Bioavailable Oxime Ether Capsid Binder With Potent Activity Against Human Rhinovirus
摘要:A Series Of Capsid-Binding Compounds Was Screened Against Human Rhinovirus (Hrv) Using A Cpe Based Assay. The Ethyl Oxime Ether 14 Was Found To Have Outstanding Anti-Hrv Activity (Median Ic50 4.75 Ng/ml),And Unlike The Equivalent Ethyl Ester Compound 3 (Pirodavir),It Has Good Oral Bioavailability,Making It A Promising Development Candidate. Compound 14 Illustrates That An Oxime Ether Group Can Act As A Metabolically Stable Bioisostere For An Ester Functionality.
Doi:10.1021/jm0202876

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-6534530-B1
优先权日:1999-08-04
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER SCOTT; ZHOU RU; WEBBER STEPHEN EVAN; PRINS THOMAS J; REICH SIEGFRIED HEINZ; KEPHART SUSAN E; RUI YUANJIN
权利人:AGOURON PHARMA
摘要:Compounds of the formula:where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:WO-2009016425-A1
优先权日:2007-08-02
标题 :Compounds of chemical synthesis with antirhinovirus activity
发明人：POMPEI RAFFAELLO; TARRO GIULIO
权利人:UNIHART CORP
摘要:The present invention relates to a lead compound UBP 502 with the formula ethyl -4- (5- (S-methylisoxazol-5-ylamino)pentyloxy)benzoate, and to a series of its analogs. UBP 502, compared to the reference compound R 77975 (Pirodavir) from the formula ethyl-4-(2-(l-(6-methylpirazine-3-iI)-43 pyperidil)etqxy benzoate presents, in vitro, a lesser cytpxicity combined with an adequate therapeutic index to envisage the potential clinical application. Moreover, when administered for oral route resulted to be bioavailable and metabolically stable compared to R 77975.

专利号:US-10092587-B2
优先权日:2014-06-25
标题:Antiviral composition containing material involved in phosphatidylcholine synthesis pathway
发明人：KWON DUR HAN; JANG MI JIN; SONG JAE HYOUNG; ENKHTAIVAN GANSUKH; OH SEI RYANG
权利人:KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY
摘要:The present invention relates to an antiviral composition comprising any one selected from the group consisting of chlorine, phosphocholine, cytidine triphosphate, CDP-choline, phosphorylcholine, and phosphatidylcholine. The antiviral composition is harmless to the human body and exhibits an excellent inhibitory effect on virus proliferation. Therefore, it can be applied to a pharmaceutical composition for preventing or treating viral diseases as well as a health functional food, a quasi-drug composition, and a feed composition for preventing or ameliorating viral diseases.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.