CAS: 113237-18-6; 5-Fluoro-6-Hydroxy-2-Oxo-1,2-Dihydropyridine-3-Carbonitrile

该化合物是一种氟丙烯衍生物,在2和6个位置的3位置和氢氧基组组中具有环丙酮替代物,该化合物因其独特的结构特征,对制药和农用化学研究具有兴趣,能够作为活性成分的构件进行潜在应用.存在电离式(cyano, 氟)和电施食(Hydroxy)组,可增强其在热循环合成中的再活动.其氟的替代可提高药物开发中的代谢稳定性和生物利用率.该化合物的多功能性使其适合于用于交叉组合反应,核分裂替代和其他合成转化,为研究人员提供专门的化学合成的有价值的中间体.

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35441-10-2 1296176-89-0 75993-41-8

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CAS号107-91-5 氰乙酰胺 | CAS号96568-04-6 3-(2,6-二氯-5-氟-3...

合成工艺路线路线简述

    📜Sodium 3-Ethoxy-2-Fluoro-3-Oxoprop-1-En-1-Olate,氰乙酰胺置于sodium Ethanolate体系中,用 乙醇 用作溶剂,化学反应 0.25H,反应生成2,6-二羟基-5-氟-3-氰基吡啶
    参考文献:Pyridonecarboxylic Acids As Antibacterial Gaents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives.
    标题:Pyridonecarboxylic Acids As Antibacterial Gaents. Viii. An Alternative Synthesis Of Enoxacin Via Fluoronicotinic Acid Derivatives.
    摘要:一种1,8-萘啶类抗菌剂依诺沙星的替代合成物被开发出来.目前的方法是通过在c-2处具有2-乙氧基羰基乙基氨基部分的5-氟烟酸乙酯的dieckmann型环化反应来构建1,8-萘啶环.这种烟酸酯是通过7个步骤从氟乙酸乙酯通过2,6-二氯-5-氟烟酸乙酯制备的.
    Doi:10.1248/cpb.35.2280

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    专利信息


    专利号:US-5204478-A
    优先权日:1992-08-20
    标题 :Process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride
    发明人：JENNINGS REX A
    权利人:WARNER LAMBERT CO
    摘要:An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.

    专利号:US-7642356-B2
    优先权日:2005-09-16
    标 题 :Process for preparing beta-ketoester compounds
    发明人：SHIN HYUN IK; CHOI BO SEUNG; LEE JAE HOON
    权利人:LG LIFE SCIENCES LTD
    摘要:The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).

    专利号:EP-0655998-B1
    优先权日:1992-08-20
    标题:Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

    专利号:EP-0655998-A1
    优先权日:1992-08-20
    标 题 :METHOD FOR THE SYNTHESIS OF 2,6-DICHLOR-5-FLUORNICOTINIC ACID AND 2,6-DICHLOR-5-FLUORNICOTINOYL CHLORIDE.

    专利号:WO-9404501-A1
    优先权日:1992-08-20
    标题 :Improved process for the synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

    专利号:CZ-286204-B6
    优先权日:1992-08-20
    标 题:Improved synthesis of 2,6-dichloro-5-fluoronicotinic acid and 2,6-dichloro-5-fluoronicotinoyl chloride

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    参考DOI号:10.1248/cpb.35.2280
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