Carboxy-Methyl-Triphenylphosphonium置于碳酸氢钠体系中,用 乙醇,水 用作溶剂,以81%的收率获得三苯基甲基氯化膦 参考文献:Galkin; Bakhtiyarova; Polezhaeva,Russian Journal Of General Chemistry,1998,Vol. 68,# 7,P. 1052-1056 标题:Galkin; Bakhtiyarova; Polezhaeva,Russian Journal Of General Chemistry,1998,Vol. 68,# 7,P. 1052-1056
专利信息
专利号:US-2018148745-A1 优先权日:2015-05-26 标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor 发明人:ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN 权利人:CALIFORNIA INST OF TECHN; PROVIVI INC 摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.
专利号:US-2023047214-A1 优先权日:2020-02-03 标题:Methods for microwave synthesis of degradable polymers for drug delivery 发明人:MURATOGLU ORHUN K; ORAL EBRU; GRINDY SCOTT 权利人:MASSACHUSETTS GEN HOSPITAL 摘要:Provided herein are methods of making degradable, additive-blended polymeric materials using microwave radiation and catalysts. The methods can include incorporation of therapeutic materials into the polymeric materials. There also are provided polymeric materials made by the methods and medical devices comprising the polymeric materials made by the methods.
专利号:US-9175026-B2 优先权日:2011-03-23 标题:Synthesis of thioether containing trialkoxysilanes 发明人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K 权利人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K; UNIV CALIFORNIA 摘要:The invention relates to a radical-initiated thiol-ene or thiol-yne “clickâ€? reaction that provides a simple and efficient route to diverse trialkoxysilanes. Trialkoxysilanes made in this way are obtained in quantitative to near-quantitative yields with high purity without any or minimal purification. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. The modular nature of these radical-based thiol-ene or thiol-yne “clickâ€? reactions allows a wide variety of pendant groups to be coupled to silane compounds that can then be coupled to a wide variety surfaces in order to modify their material properties. Consequently, such radical initiated thiol-ene and thiol-yne reactions provide facile and efficient methods for preparing an enormous number of surface-active functional trialkoxysilanes.
专利号:US-8853410-B2 优先权日:2009-04-30 标 题:Process for preparing substituted isoxazoline compounds and their precursors 发明人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN 权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE 摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.
专利号:US-2008214386-A1 优先权日:2004-03-01 标题:Catalyst for Cyclic Carbonate Synthesis 发明人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU 摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.
专利号:US-4374770-A 优先权日:1981-10-08 标题:Process for preparation of aromatic acid chlorides 发明人:HYATT JOHN A; KASHDAN DAVID S 权利人:EASTMAN KODAK CO 摘要:Disclosed is a process for converting aromatic aldehydes to the corresponding acid chlorides by reacting an aromatic aldehyde with sulfuryl chloride in the presence of a catalytic amount of a phosphine, phosphine oxide or phosphonium compound. The product compounds produced by the process of this invention are useful as chemical synthesis intermediates in the preparation of pharmaceuticals, dyes, herbicides and photographic chemicals.