CAS: 96027-74-6; (2-Butylbenzofuran-3-yl)(4-(2-(Ethylamino)Ethoxy)-3,5-Diiodophenyl)Methanone Hydrochloride
该化合物是通过肝新陈代谢形成的抗亚胺酮的代谢物,它保留了药理活动,有助于母体化合物的治疗效应.这种盐分形式提高了溶性与稳定性,促进了研究和分析应用.脱乙胺酮盐分在药理,基因和代谢研究中特别宝贵,因为它有助于阐明氨酮的处置和行动机制. 它的精细结构和纯度使它适合用作HPLC,LC-MS和其他分析技术的参考标准.该化合物还被用于调查氨碘酮的长期功效和潜在副作用,支持心血管药物研究的进展.
- 英文名称(2-Butylbenzofuran-3-yl)(4-(2-(Ethylamino)Ethoxy)-3,5-Diiodophenyl)Methanone Hydrochloride
- 中文名称去乙基胺碘酮盐酸盐
- IUPAC名称(2-butylbenzofuran-3-yl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone hydrochloride
- 其它别名Methanone,(2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-,hydr°Chloride (9CI)
- CAS编号96027-74-6
- MFCD编号:MFCD08060094
- EINECS号:642-236-2
- 分子式:C23H26ClI2NO3分子量:653.73
- 产品CID: 2015832
- 同类组份化合物CAS83409-32-9 (free base)96027-74-6 (HCl)
- 产品分类分析化学 → 标准品 → 标准物质
物理性质
MSDS等安全信息
上下游产品
CAS号4535-87-9 2-氯-N-乙基乙胺盐酸盐 | CAS号1951-26-4 2-丁基-3-(3,5-二碘-... | CAS号1096359-59-9 {4-[2-(benzyl-e...合成工艺路线路线简述
- 19774-82-4 = 96027-74-6
反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Ethyl Acetate,Water; 0.5 H,Rt1.2 Reagents: 1-Chloroethyl Chloroformate Solvents: Toluene; 16 H,Reflux1.3 Reagents: Hydrochloric Acid Solvents: Methanol; Rt
标题:Preparation And Purification Of Desethylamiodarone Hydrochloride
作者:Lucas,Anthony N.; Tanol,Mehmet; Mcintosh,Michelle P.; Rajewski,Roger A.
参考文献:Synthetic Communications 日期:2006 卷标:36(22) 页码:3371-3376
📜{4-[2-(Benzyl-Ethyl-Amino)-Ethoxy]-3,5-Diiodo-Phenyl}-(2-Butyl-Benzofuran-3-yl)-Methanone置于1-氯乙基氯甲酸酯,盐酸体系中,用 1,2-二氯乙烷,甲醇,水,乙酸乙酯 作为反应溶剂,化学反应 3.0H,反应生成 去乙基胺碘酮盐酸盐
参考文献:Trace Amine-Associated Receptor 1 (Taar1) Is Activated By Amiodarone Metabolites
标题:Trace Amine-Associated Receptor 1 (Taar1) Is Activated By Amiodarone Metabolites
摘要:Amiodarone (Cordarone,Wyeth-Ayerst Pharmaceuticals) Is A Clinically Available Drug Used To Treat A Wide Variety Of Cardiac Arrhythmias. We Report Here The Synthesis And Characterization Of A Panel Of Potential Amiodarone Metabolites That Have Significant Structural Similarity To Thyroid Hormone And Its Metabolites The Iodothyronamines. Several Of These Amiodarone Derivatives Act As Specific Agonists Of The G Protein-Coupled Receptor (Gpcr) Trace Amine-Associated Receptor 1 (Taar(1)). This Result Demonstrates A Novel Molecular Target For Amiodarone Derivatives With Potential Clinical Significance. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2008.08.013
海关参考信息
- 2912110000-甲醛
2912210000-苯甲醛
2922110001-单乙醇胺
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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主要参考文献
1: Colvin RA, Oibo JA, Allen RA, Tyler L, Leek D. Interaction of amiodarone and desethylamiodarone with the cardiac muscarinic receptor in vitro. J Mol Cell Cardiol. 1989 May;21(5):453-60. doi: 10.1016/0022-2828(89)90785-2. 42(1):29-36. doi: 10.1007/s13318-015-0315-0.
146:188-198. doi: 10.1016/j.bcp.2017.09.012. Epub 2017 Sep 25. 4(3):251-4. doi: 10.1023/a:1016468430618.
107:67-80. doi: 10.1016/j.bcp.2016.03.005. Epub 2016 Mar 10. 9(2):e87150. doi: 10.1371/journal.pone.0087150.
合成参考文献
合成方法参考DOI号:10.1124/jpet.106.108993
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