CAS: 80510-06-1; 2-(4-Hydroxy-3-Methoxyphenyl)-N-(4-Hydroxyphenethyl)-5-(3-((4-Hydroxyphenethyl)Amino)-3-Oxoprop-1-En-1-yl)-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxamide
该化合物是一种属于氨化物类别的化学化合物,其特征是结构特征,包括碳基(C=O)直接与氮原子(N)结合,氨化物的典型特征是氨化物;Grosamide经常用于各种工业应用,包括作为表面活性剂或农业化学品的配制;其特性可能包括有机溶剂中的中等溶解性,以及在水解或恐吓反应等特定条件下的潜在反应.该化合物的安全特征和环境影响是基本考虑因素,与许多化学物质一样,并须接受监管评估.尽管熔点,沸点和密度等具体的物理和化学特性可能各不相同,但它们对于了解其在不同应用中的行为至关重要.
- 英文名称2-(4-Hydroxy-3-Methoxyphenyl)-N-(4-Hydroxyphenethyl)-5-(3-((4-Hydroxyphenethyl)Amino)-3-Oxoprop-1-En-1-yl)-7-Methoxy-2,3-Dihydrobenzofuran-3-Carboxamide
- 中文名称克罗酰胺
- IUPAC名称2-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenethyl)-5-(3-((4-hydroxyphenethyl)amino)-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzofuran-3-carboxamide
- 其它别名Grossamide; 3-Benzofurancarboxamide, 2,3-Dihydro-2-(4-Hydroxy-3-Methoxyphenyl)-N-(2-(4-Hydroxyphenyl)Ethyl)-5-((1E)-3-((2-(4-Hydroxyphenyl)Ethyl)Amino)-3-Oxo-1-Propenyl)-7-Methoxy-, (2R,3R)-Rel-; 3-Benzofurancarboxamide, 2,3-Dihydro-2-(4-Hydroxy-3-Methoxyphenyl)-N-[2-(4-Hydroxyphenyl)Ethyl]-5-[(1E)-3-[[2-(4-Hydroxyphenyl)Ethyl]Amino]-3-Oxo-1-Propen-1-Yl]-7-Methoxy-, (2R,3R)-Rel-; (2S,3S)-2-(4-Hydroxy-3-Methoxyphenyl)-N-[2-(4-Hydroxyphenyl)Ethyl]-5-[(E)-3-[2-(4-Hydroxyphenyl)Ethylamino]-3-Oxoprop-1-Enyl]-7-Methoxy-2,3-Dihydro-1-Benzofuran-3-Carboxamide
- CAS编号80510-06-1
- MFCD编号:MFCD26131301
- FDA UNII编号:63RFK5Z1GK
- 分子式:C36H36N2O8分子量:624.69
- 产品CID: 1800350
- 产品分类天然产物 → 生物碱
物理性质
MSDS等安全信息
上下游产品
CAS号65646-26-6 feruloyltyramine | CAS号66648-43-9 N-反式阿魏酰酪胺合成工艺路线路线简述
- 51-67-2 + 1135-24-6 = 80510-06-1
反应条件:1.1 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,Phosphorus(1+),Bromotri-1-Pyrrolidinyl-,(T-4)-,Hexafluorophosphate(1-) (1:1) Solvents: Dimethylformamide1.2 Solvents: Tetrahydrofuran1.3 Reagents: Carbamide Peroxide,Monosodium Phosphate Solvents: Acetone,Water; Ph 4.5,Rt
标题:Preparation Of The Neolignan Natural Product Grossamide By A Continuous-Flow Process
作者:Baxendale,Ian R.; Et Al
参考文献:Synlett 日期:2006 卷标:(3) 页码:427-430]
51-67-2 = 80510-06-1
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 6 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt1.3 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dimethylformamide; 40 H,Rt2.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: 1,2-Dichloroethane; 1 D,60 °C
标题:Comparative Analysis Of Stilbene And Benzofuran Neolignan Derivatives As Acetylcholinesterase Inhibitors With Neuroprotective And Anti-Inflammatory Activities
作者:Nagumo,Mina; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(17) 页码:2475-2479]
537-98-4 + 51-67-2 = 80510-06-1
反应条件:1.1 Reagents: Triethylamine Solvents: Dimethylformamide; 10 Min,0 °C1.2 Reagents: Bop Reagent Solvents: Dichloromethane; 30 Min,0 °C; 20 H,Rt2.1 Solvents: Ethyl Acetate,Water; 4 H,Ph 4.7,Rt
标题:Dihydrobenzofuran Neolignanamides: Laccase-Mediated Biomimetic Synthesis And Antiproliferative Activity
作者:Cardullo,Nunzio; Et Al
参考文献:Journal Of Natural Products 日期:2016 卷标:79(8) 页码:2122-2134]
66648-43-9 = 80510-06-1 + 163136-16-1 + 163136-20-7
反应条件:1.1 Catalysts: Iron Chloride (Fecl3)
标题:Concise Synthesis Of Cannabisin G
作者:Li,Dawei; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(17) 页码:5095-5098]
= 80510-06-1
反应条件:1.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: 1,2-Dichloroethane; 1 D,60 °C
标题:Comparative Analysis Of Stilbene And Benzofuran Neolignan Derivatives As Acetylcholinesterase Inhibitors With Neuroprotective And Anti-Inflammatory Activities
作者:Nagumo,Mina; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(17) 页码:2475-2479]
66648-43-9 = 80510-06-1
反应条件:1.1 Solvents: Ethyl Acetate,Water; 4 H,Ph 4.7,Rt
标题:Dihydrobenzofuran Neolignanamides: Laccase-Mediated Biomimetic Synthesis And Antiproliferative Activity
作者:Cardullo,Nunzio; Et Al
参考文献:Journal Of Natural Products 日期:2016 卷标:79(8) 页码:2122-2134]
= 80510-06-1
反应条件:1.1 Reagents: Diisopropylethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; Overnight,Rt2.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 6 H,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt2.3 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dimethylformamide; 40 H,Rt3.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: 1,2-Dichloroethane; 1 D,60 °C
标题:Comparative Analysis Of Stilbene And Benzofuran Neolignan Derivatives As Acetylcholinesterase Inhibitors With Neuroprotective And Anti-Inflammatory Activities
作者:Nagumo,Mina; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(17) 页码:2475-2479]
22329-76-6 = 80510-06-1
反应条件:1.1 Reagents: Silver Oxide (Ag2O) Solvents: Acetone,Toluene; 28 H,0 °C2.1 Reagents: Diisopropylethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; Overnight,Rt3.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 6 H,Rt3.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt3.3 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dimethylformamide; 40 H,Rt4.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: 1,2-Dichloroethane; 1 D,60 °C
标题:Comparative Analysis Of Stilbene And Benzofuran Neolignan Derivatives As Acetylcholinesterase Inhibitors With Neuroprotective And Anti-Inflammatory Activities
作者:Nagumo,Mina; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(17) 页码:2475-2479]
1135-24-6 = 80510-06-1
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methanol; 1 H,Rt2.1 Reagents: Silver Oxide (Ag2O) Solvents: Acetone,Toluene; 28 H,0 °C3.1 Reagents: Diisopropylethylamine Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; Overnight,Rt4.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane,Water; 6 H,Rt4.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt4.3 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dimethylformamide; 40 H,Rt5.1 Reagents: Carbon Tetrabromide,Triphenylphosphine Solvents: 1,2-Dichloroethane; 1 D,60 °C
标题:Comparative Analysis Of Stilbene And Benzofuran Neolignan Derivatives As Acetylcholinesterase Inhibitors With Neuroprotective And Anti-Inflammatory Activities
作者:Nagumo,Mina; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2019 卷标:29(17) 页码:2475-2479]
66648-43-9 = 80510-06-1
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Peroxidase
标题:Concise Synthesis Of Cannabisin G
作者:Li,Dawei; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(17) 页码:5095-5098
📜阿魏酸 在 4-二甲氨基吡啶,四溴化碳,硫酸,1-羟基苯并三唑,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,N,N-二异丙基乙胺,三苯基膦,Sodium Hydroxide,Silver(L) Oxide体系中,用 1,4-二氧六环,甲醇,二氯甲烷,1,2-二氯乙烷,N,N-二甲基甲酰胺,丙酮,甲苯作为反应溶剂,反应 102.0H,获得 Grossamide
参考文献:二苯乙烯和苯并呋喃新木脂衍生物作为乙酰胆碱酯酶抑制剂具有神经保护和抗炎活性的比较分析.
标题:二苯乙烯和苯并呋喃新木脂衍生物作为乙酰胆碱酯酶抑制剂具有神经保护和抗炎活性的比较分析.
摘要:Stilbenes和苯并呋喃新木脂素是植物酚类的重要组成部分,因此它们在植物和人类健康中发挥着重要作用.这项研究的目的是研究天然存在的1,2-二苯乙烯和苯并呋喃新木脂素衍生物作为乙酰胆碱酯酶抑制剂的构效关系.制备了一系列这些化合物,并评估了它们对乙酰胆碱酯酶活性的抑制作用.δ-Viniferin,萜烯反式-脱氢二聚体,Pallidol,Grossamide和boehmenan发挥了乙酰胆碱酯酶抑制潜能.几种寡聚化合物可防止t-Bhp暴露引起的细胞损伤,并抑制脂多糖/干扰素-γ(Lps /Ifnγ)诱导的no的体外产生.我们的发现凸显了蝶草烯反式-脱氢二聚体,Pallidol和boehmenan作为治疗神经退行性疾病的多功能保健品的巨大潜力.
Doi:10.1016/J.Bmcl.2019.07.026
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1271/bbb1961.45.2593
摘要:YOSHIHARA T, YAMAGUCHI K, TAKAMATSU S, SAKAMURA S. Phenolic compounds from the roots of Solanaceae plants. A new lignan amide, grossamide, from bell pepper (Capsicum annuum var. grossum). Agricultural and Biological Chemistry. 1981;45(11):2593–8. doi: 10.1271/bbb1961.45.2593.
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