CAS: 800402-06-6; 6-Chloro-3-Iodopyridin-2-Amine

该化合物是一种杂环有机化合物,其特征是存在一个有六人组成的芳香环,含有一个氮原子.该化合物的特点是六点方位的氯原子和三点方位的碘原子,以及双点的氨基生物群(-NH2),这种替代模式有助于其独特的化学特性,包括氨基组的存在导致核生殖替代反应中的潜在再活动.卤素代成分(氯和碘)也可影响该化合物的再活动性和稳定性,使其在各种合成应用中,特别是在医药化学和材料科学中引起兴趣.卤素的存在往往会增强该化合物的脂质性,从而影响其生物活动和其他分子的相互作用.此外,该化合物的分子结构表明,在药物或农用化学组的开发中,有可能发生再生作用,从而改变丙型环的生物活动.

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1622407-12-8 1221398-11-3 1207625-23-7

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上下游产品

2-氨基-6-氯吡啶 6-Chloropyridin-2-Amine 45644-21-1

合成工艺路线路线简述

  • 800402-05-5 = 800402-06-6
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 14 H,Reflux
    标题:Discovery And Optimization Of Indoles And 7-Azaindoles As Rho Kinase (Rock) Inhibitors (Part-I)
    作者:Chowdhury,Sarwat; Sessions,E. Hampton; Pocas,Jennifer R.; Grant,Wayne; Schroeter,Thomas; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(23) 页码:7107-7112
📜2-氨基-6-氯吡啶置于盐酸,叔丁基锂,三乙胺体系中,用 四氢呋喃,1,4-二氧六环,甲苯,正戊烷 作为反应溶剂,化学反应 24.0H,反应生成 2-氨基-3-碘-6-氯吡啶
参考文献:Tyk2 Inhibitors And Uses Thereof
标题:Tyk2 Inhibitors And Uses Thereof
摘要:本发明提供了化合物,其组合物以及使用这些化合物来抑制tyk2并治疗tyk2介导的疾病的方法.

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专利信息


专利号:WO-2011050245-A1
优先权日:2009-10-23
标 题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.

专利号:US-12233062-B2
优先权日:2018-09-26
标 题 :Heterocyclic derivatives useful as SHP2 inhibitors
发明人：HAN HUIFENG; GAO PANLIANG; MA CUNBO; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention provides a compound of formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention provides a pharmaceutical composition comprising the said compound.

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合成参考文献


摘要:Mérour, J.-Y.; Joseph, B., Science of Synthesis Knowledge Updates, (2016) 3, 52.
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