CAS: 76541-44-1; 3-(Difluoromethyl)Pyridine

相似化合物

3796-23-4 1374659-24-1 20857-47-0

上下游产品

CAS号500-22-1 吡啶-3-甲醛

📜3-吡啶甲醛置于potassium Fluoride,甲酸,四甲基氟化铵,N,N-硫酰二咪唑体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,以68%的收率获得产物3-(二氟甲基)吡啶
参考文献:硫酰氟和四甲基氟化铵在室温下对苯甲醛和α-酮酸酯进行脱氧氟化
标题:硫酰氟和四甲基氟化铵在室温下对苯甲醛和α-酮酸酯进行脱氧氟化
摘要:描述了使用硫酰氟和me 4 Nf在室温下对苯甲醛和α-酮酸酯进行脱氧氟化的方法.证明了大范围的芳基和杂芳基底物,并且该方法与许多底物的其他常见脱氧氟化方法相比具有优势.
DOI:10.1021/acs.Orglett.9B00054

专利信息

专利号:US-2023174567-A1
优先权日:2020-05-22
标题:Synthesis of fluorinated nucleotides
发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

专利号:WO-2021236859-A1
优先权日:2020-05-22
标题 :Synthesis of fluorinated nucleotides

专利号:CN-117304094-A
优先权日:2023-09-21
标 题 :Synthesis method of 3-trifluoromethyl pyridine or 3-difluoro methyl pyridine compound