CAS: 57543-60-9; 7-Methoxy-2H-Chromene-3-Carboxylic Acid

该化合物是一种铬衍生物,在7号位置上有一个甲氧替代物,在3号位置上有一个碳本体酸功能组,该化合物是有机合成的多用途中间体,特别是在开发药品,农用化学品和精美化学品方面.其铬核心结构提供了潜在的生物活动,使其在药用化学研究中具有价值.甲基氧组增强了溶性性和稳定性,而氨本体酸混合物则通过酯化,恐吓或其他衍生反应进一步实现功能化.该化合物的特点是高度纯度和一贯性,确保了合成应用的可靠性能.其定义明确的结构有利于对定向分子设计进行精确的修改.

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上下游产品

3-(2-formyl-5-methoxy-phenoxy)-propionic acid 7-methoxybenzo-2H-pyran-3-carbonitrile 7-Methoxy-2H-chromene-3-carboxylic acid amide 7-Methoxy-2H-chromene-3-carboxylic acid tert-butyl ester 7-methoxychromane-3-carboxylic acid carbomethoxy-3 methoxy-7 2H chromene 7-methoxychroman-3-one pyrano[3,2-g][1]benzopyran-2-one

合成工艺路线路线简述

    📜7-甲氧基-2H-色烯-3-甲腈置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 6.0H,以80%的收率获得产物7-甲氧基-2H-苯并吡喃-3-羧酸
    参考文献:作为抗血管反应生成和抗癌药 的新型2-(取代的2 H-铬-3-基)-5-芳基-1 H-咪唑衍生物的合理设计和合成†
    标题:作为抗血管反应生成和抗癌药 的新型2-(取代的2 H-铬-3-基)-5-芳基-1 H-咪唑衍生物的合理设计和合成†
    摘要:基于较早已证明的癌症药效团类似物,通过色烯-3的反应合理设计并合成了新型的2-(取代的2 H-铬烯-3-基)-5-芳基-1氢咪唑(13-16).tea存在的条件下,用取代的酰基溴反应生成-羧酸(10A-D),然后在甲苯中与nh 4 Oac回流.体外筛选了化合物13-16抑制kras / Wnt及其抗血管反应生成特性.化合物16F已被鉴定为有效的抗血管反应生成分子,可以被认为是一种新的先导结构.分子对接分析显示出较高的结合亲和力16F与kras,Wnt和vegf结合使用.
    DOI:10.1039/c4Ra09945A

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    专利信息


    专利号:US-6538094-B2
    优先权日:1998-12-21
    标题:Process for synthesis of allophanate compounds and compositions including the product thereof
    发明人：TAZZIA CHARLES L
    权利人:BASF CORP
    摘要:The invention provides a process for preparing an allophanate-containing compound in the presence of a metal catalyst and a tertiary amine. In a preferred process, the tertiary amine compound also has a hydroxyl group. The hydroxyl group can react with the isocyanate functionality. Also disclosed is a process in which an allophanate-containing compound is prepared with copper acetate monohydrate as a catalyst. The allophanate-containing compound is used as a curing agent in coating compositions, particularly electrocoat coating compositions. The coating compositions are used to coat articles.

    专利号:WO-0037570-A1
    优先权日:1998-12-21
    标题:Process for synthesis of allophanate compounds and compositions including the product thereof

    专利号:ES-2285867-T3
    优先权日:1998-12-21
    标 题 :PROCESS FOR THE SYNTHESIS OF ALOFANATE COMPOUNDS AND COMPOSITIONS THAT CONTAIN THEM.

    专利号:US-6228472-B1
    优先权日:1998-12-21
    标 题 :Process for synthesis of allophanate compounds and compositions including the product thereof

    专利号:US-2001007012-A1
    优先权日:1998-12-21
    标题:Process for synthesis of allophanate compounds and compositions including the product thereof

    专利号:CA-2355935-A1
    优先权日:1998-12-21
    标 题:Process for synthesis of allophanate compounds and compositions including the product thereof

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    合成参考文献

    参考DOI号:10.1021/ja00073a074
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