CAS: 56777-24-3; Benzyl (S)-Lactate

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CAS号79-33-4 L-(+)-乳酸 | CAS号100-39-0 溴化苄 | CAS号1760-46-9 二苯基醋酸酐 | CAS号2051-96-9 乳酸苄酯 | CAS号117-34-0 2,2-二苯基乙酸 | CAS号93-97-0 苯甲酸酐 | CAS号794-94-5 4-甲氧基羟苯甲酸酐 | CAS号13076-17-0 D-丙交酯 | CAS号100-51-6 苯甲醇

L-乳酸,溴甲苯置于1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 30.0H,以76%的收率获得产物(S)-(-)-乳酸苄酯
参考文献:Cyclic Hydroxamates,Especially Multiply Substituted [1,2]Oxazinan-3-Ones
标题:Cyclic Hydroxamates,Especially Multiply Substituted [1,2]Oxazinan-3-Ones
摘要:报道了将假定的n-酰-D-阿拉-D-阿拉替代物的合成途径,从将4,5和6元环内酯转化为5,6和7元环氢氧化物开始.合成的关键步骤是ω-氨氧酯的三甲基铝促进的环化反应.7元环氢氧化物以椅式构象结晶.将反应序列扩展到同型丝氨酸或同型丝氨酸内酯会导致环康纳林和n-酰化环康纳林的形成.环康纳林的4-苯乙酰氨基衍生物以船式构象结晶.在环康纳林的4-酰氨基环康纳林的环氮上附加2-羧基丙基取代基,可以通过将无环氨氧酯前体与苄乳酸三甲酯的三氟甲磺酸酯偶联,或在环化之后,通过与三氟甲基丙酸叔丁酯在氟化钾-氧化铝存在下偶联,然后在每种情况下去除保护基来实现.通过4-苯乙酰氨基环康纳林与苄基2-氧戊二酸酯在异亚胺存在下反应,然后进行氢解,合成了抗生素拉维西汀的六元同系物.从甲基2,4-二溴-2,4-二去氧-L-赤葡萄糖酸甲酯开始,该物质可以从抗坏血酸中经过两步合成,这些反应序列已被应用于立体特异性合成一种d-丙氨酸衍生物,其氮原子被包含在一个3,4-二取代[1,2]噁唑烷-3-酮内.关键词:D-Ala-D-Ala替代物,环康纳林,同型拉维西汀,肽聚糖,三甲基铝.
DOI:10.1139/v03-122

专利信息

专利号:EP-3480195-A1
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
权利人:BAYER ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, involving specific carboxylic acid group protecting tags: nTAG is preferably: nwherein m is ‰¥ 15 to ‰¤ 25, p is ‰¥ 8 to ‰¤ 18 and q is ‰¥ 15 to ‰¤ 25.

专利号:US-12122759-B2
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
发明人：HEIMBACH DIRK; OMURA SATOSHI; SUNAZUKA TOSHIAKI; HIROSE TOMOYASU; NOGUCHI YOSHIHIKO; Köbberling Johannes; WU ZHIJIE; FU SHUIBIAO; WU WEI; QIU JINFENG; HE LIU; WEI XUDONG
权利人:ELANCO ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.

专利号:US-6861416-B2
优先权日:2001-08-03
标题 :Oxazinones and methods for their use and synthesis
发明人：WOLFE SAUL; SHUSTOV GENNADY
权利人:CHIROLOGIX PHARMACEUTICALS INC
摘要:The invention pertains, at least in part, to new intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The invention also pertains to novel olefinic oxazinone compounds, methods for their synthesis, and methods of using these compounds for the synthesis of oxazinones. The invention also pertains to methods for using the compounds to treat bacterial associated states in subjects.

专利号:US-2025019360-A1
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides

专利号:US-2003232820-A1
优先权日:2001-08-29
标题:Method for synthesizing oxazinones
发明人：WOLFE SAUL; WILSON MARIE-CLAIRE; CHENG MING-HUEI
摘要:New methods and intermediates are discussed for the stereospecific synthesis of oxazinone compounds.

专利号:EP-3676265-B1
优先权日:2017-11-07
标题 :Method for the synthesis of cyclic depsipeptides