CAS: 56211-40-6; N-(Isopropylcarbamoyl)-4-(M-Tolylamino)Pyridine-3-Sulfonamide

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CAS号72811-73-5 4-(间甲苯氨基)吡啶-3-磺胺 | CAS号1795-48-8 异丙基异氰酸酯 | CAS号17614-10-7 Carbamic acid,N... | CAS号160822-47-9 4-[(3-Methylphe... | CAS号51498-37-4 4-羟基吡啶-3-磺酸 | CAS号33263-43-3 4-氯吡啶-3-磺酰胺 | CAS号108-44-1 3-甲基苯胺

Torsemide Lithium置于溶剂黄146体系中,用 二甲基亚砜 作为反应溶剂,化学反应 1.0H,反应生成 托拉塞米
参考文献: Process For The Preparation Of Highly Pure Torsemide[fr] Methode De Preparation De Torsemide De Purete Elevee
标题: Process For The Preparation Of Highly Pure Torsemide[fr] Methode De Preparation De Torsemide De Purete Elevee
摘要:本发明提供了一种新型方法,通过在锂碱(f I,Ii)存在下,将4-甲基苯胺基-3-吡啶磺酰胺[2]与苯基异丙基氨基甲酸酯反应,制备高纯度托瑟米特[1].本发明还提供了一种新型中间体-托瑟米特锂,也可以是水合物或溶剂合物形式-这是一种稳定的固体化合物,可以简单地从反应混合物中分离出来,在酸化后得到几乎纯净的托瑟米特[1],无需进一步纯化步骤.

专利信息

专利号:US-2004138469-A1
优先权日:2002-12-23
标 题 :Process for the synthesis of torsemide, in particular of pure and stable form II
发明人：LUSSANA MASSIMILIANO; RAINONI MAURO; GAMBUZZA FILIPPO
权利人:COSMA S P A
摘要:The present invention relates to a new process for the synthesis of torsemide, in particular of pure and stable form II, which comprises direct synthesis of torsemide from 4-(3-methylphenylamino)-3-pyridine-sulphonamide. The new process envisages fewer steps than the processes described in the prior art, with improved yields and good quality from the chemical and preferably polymorphous points of view.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2024368164-A1
优先权日:2021-04-28
标 题 :Purine nucleosides, their intermediates, and methods of preparation thereof
发明人：RAVI RAMA SURESH; JACOBSON KENNETH A; POE RUSSELL BIRCH
权利人:ASTROCYLE PHARMACEUTICALS INC; US HEALTH
摘要:The present invention provides purine nucleoside analog compounds and methods of use thereof for treatment of certain injuries, disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. The present invention further provides methods of synthesizing such compounds, and intermediates useful in the synthesis of such compounds.

专利号:EP-1532112-B1
优先权日:2002-07-19
标 题 :Process for the preparation of modification i of n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide
发明人：FILIC DARKO; DUMIC MILJENKO; DANILOVSKI ALEKSANDAR; KLEPIC BOZENA; FISTRIC INES; MARINKOVIC MARINA; HORVAT-MIKULCIC JASNA
权利人:PLIVA HRVATSKA D O O
摘要:The invention relates to a new process for the preparation of modification I of torasemide by precipitation with acids from an alkaline extract of the original reaction mixture of the last phase in the synthesis of torasemide.