CAS: 475-83-2; Nuciferine

上下游产品

diazomethane (-)-N-methylasimilobine diazomethyl-trimethyl-silane 2-(3,4-dimethoxyphenyl)-ethylamineatherosperminine (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-1,2-diol dehydronuciferine (6aR)-1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

N-(3,4-二甲氧基苯乙基)乙酰胺置于三乙胺,Cesium Fluoride,Sodium Hydroxide,Lithium Hydroxide,三氯氧磷体系中,用 甲醇,乙醇,二氯甲烷,水,甲苯,乙腈 作为反应溶剂,化学反应 27.67H,反应生成 荷叶碱
参考文献:使用苯并炔化学的立体选择性全合成(S)-和(R)-核苷
标题:使用苯并炔化学的立体选择性全合成(S)-和(R)-核苷
摘要:(S)-和(R)-核苷的总合成是通过涉及手性二氢异喹啉烯酰胺与csf促进的2-(三甲基甲硅烷基)苯基三氟甲磺酸酯之间的非对映选择性反应的方法完成的,从而提供了可分离的非对映异构体混合物,从而提供了(S)-和(R)-核苷通过简单而有效的转化.
DOI:10.1016/j.Tet.2020.131461

专利信息

专利号:US-12091696-B2
优先权日:2022-08-10
标 题 :O-methyltransferase protein with highly specific catalytic function for multiple bias parent nuclei and encoding gene and use thereof
发明人：CHEN SHA; YU YUETONG
权利人:INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS
摘要:The present disclosure provides an O-methyltransferase protein with a highly specific catalytic function for multiple benzylisoquinoline alkaloids (BIAs) parent nuclei and an encoding gene and use thereof. Compared with wild-type O-methyltransferase, the O-methyltransferase protein (SEQ ID NO: 2) shows an enhanced enzymatic activity and a wider substrate scope. The O-methyltransferase protein can catalyze O-methylation of backbones from three BIAs, including monobenzylisoquinolines (norcoclaurine, coclaurine, and N-methylcoclaurine), aporphines (asimilobine and N-methylasimilobine), and protoberberines (scoulerine and tetrahydrocolumbamine). Meanwhile, this O-methyltransferase protein is highly regioselective for each backbone. The O-methyltransferase protein catalyzes methylation of the monobenzylisoquinolines at 6-OH and 7-OH, is only active on 6-OH of the backbone of the aporphines, and mainly catalyzes methylation of the protoberberines at 2-OH. Moreover, the O-methyltransferase protein has a stronger catalytic activity and can be used as a biocatalyst for the semi-synthesis of related compounds.

专利号:US-4013664-A
优先权日:1973-06-20
标 题:Synthesis of hernandaline
发明人：KUPCHAN S MORRIS; KAMESWARAN VENKATARAMAN
权利人:RESEARCH CORP
摘要:There is disclosed a novel and improved method of synthesizing aporphines utilizing the Pschorr cyclization of 1-(2'-aminobenzyl)-7 hydroxy-1,2,3,4-tetrahydroisoquinolines in place of the corresponding 7-methoxy compounds. n In the novel process of the present invention the amino group is diazotized and cyclized in the presence of copper powder.

专利号:EP-4495102-A4
优先权日:2022-03-22
标 题 :PROCESS FOR THE SYNTHESIS OF NUCIFERINE OR A DERIVATIVE THEREOF, NUCIFERINE DERIVATIVE AND USE THEREOF

专利号:CN-114891840-A
优先权日:2022-05-23
标 题 :Application of lotus leaf O-methyltransferase and its encoding gene in the synthesis of benzylisoquinoline alkaloids and phenylpropionic acids

专利号:CN-116478941-A
优先权日:2023-02-27
标 题:Application of CYP80G protein and its coding gene in catalyzing the synthesis of aporphine alkaloids in lotus leaf

专利号:CN-114891840-B
优先权日:2022-05-23
标题:Lotus leaf O-methyltransferase and application of encoding gene thereof in synthesis of benzyl isoquinoline alkaloid and phenylpropionic acid compounds