CAS: 4747-71-1; Isocyanatocyclopentane

上下游产品

phosgene Cyclopentamine Cyclopentyl bromide silver (I) nitro cyanamide1-cyclopentyl-3-phenylurea 1-Cyclopentyl-3-(2-dimethylamino-6-methoxy-phenyl)-urea -esterN-Cyclopentyl-carbaminsaeure-3-(p-fluorphenyl)-3-phenyl-propin-(1)-yl-(3)-ester (R)-tert-butyl 2-(3-cyclopentylureido)-2-phenylacetate

环戊胺置于三乙胺体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,反应生成 环戊基异氰酸酯
参考文献:Organosilicon Synthesis Of Isocyanates: Ii. Synthesis Of Aliphatic,Carbocyclic,And Fatty-Aromatic Isocyanates
标题:Organosilicon Synthesis Of Isocyanates: Ii. Synthesis Of Aliphatic,Carbocyclic,And Fatty-Aromatic Isocyanates
摘要:Silylation Of A Series Of Aliphatic,Carbocyclic,And Fatty-Aromatic Amines Gave The Corresponding Silyl Derivatives Whose Yield Depended On The Electronic And Steric Structure Of The Substrate And The Nature Of The Silylating Agent. The Yield Of Isocyanates Obtained By Phosgenation Of The Silyl Derivatives Under Mild Conditions Decreased In Going From Aliphatic Amines To Benzylamines And Rose As The Length Of The Alkyl Chain In Fatty-Aromatic Amines Extended. The Most Convenient Procedure For The Synthesis Of Low-Boiling Alkyl Isocyanates Was Found To Be Based On The Transformation Of Amines Or Ammonium Salts Into Silyl Or Silyl Silyl-Carabamates. Followed By Pyrolysis Of The Latter In The Presence Of Trichloro(Phenyl)Silane.
DOI:10.1134/s1070363206030182

专利信息

专利号:US-2019211134-A1
优先权日:2016-08-19
标 题 :Thiourethane polymers, method of synthesis thereof and use in fused filament fabrication printing
发明人：ELLSON GREGORY T; LUND BENJAMIN R; VOIT WALTER
权利人:BOARD OF REGENTS THE UNIV OF TEXAS; ADAPTIVE 3D TECH
摘要:A thermoplastic thiourethane polymer comprising a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiourethane linkages. The first type of monomer includes two or more thiol functional groups and the type of monomer includes two or more isocyanate functional groups. The first and second types of monomers are polymerized together in an anhydrous aprotic solvent-dissolved anionic step-growth polymerization reaction that is catalyzed by a non-nucleophillic base having a pKa greater than 7.

专利号:US-10899072-B2
优先权日:2016-03-15
标题:Thiourethane polymers, method of synthesis thereof and use in additive manufacturing technologies
发明人：ELLSON GREGORY T; LUND BENJAMIN R; VOIT WALTER
权利人:UNIV TEXAS; ADAPTIVE 3D TECH; BOARD OF RESENTS THE UNIV OF TEXAS SYSTEM
摘要:A semi-crystalline thiourethane polymer. The semi-crystalline thiourethane polymer comprises a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiourethane linkages. Each of the first type of monomer includes two or more thiol functional groups and each of the second type of monomer includes two or more isocyanate functional groups. The first and second types of monomers are polymerized together in an anionic step-growth polymerization reaction that is catalyzed by a non-nucleophillic base having a pKa greater than 7, produced by photo-initiated decomposition of a photolatent base. A method of synthesizing, and polymer jetting and stereolithography methods of manufacturing a polymer part, are also disclosed.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-4366317-A
优先权日:1981-06-22
标题 :Process for synthesis of N-(hydrocarbyl)substituted-p-menthane-3-carboxamide
发明人：HAUT STEPHEN A; COMES ROGER A
权利人:PHILIP MORRIS INC
摘要:This invention provides an improved process for synthesizing carboxamides which involves reacting 3-p-menthyl halide with magnesium to form 3-p-menthylmagnesium halide Grignard reagent, and reacting the Grignard reagent with hydrocarbyl isocyanate at a temperature below about -20 DEG C. to form N-hydrocarbyl-p-menthane-3-carboxamide product. The product comprises a mixture of geometric isomers in which the 3-p-menthyl:3-p-neomenthyl weight ratio is at least 4:1 and can be as high as 9:1 under optimal conditions. This invention also provides a novel process for producing acylurea compounds such as N-(3-p-menthylcarbonyl)-N-t-butyl-N'-t-butylurea.

专利号:US-2022281888-A1
优先权日:2019-09-25
标题:Bicyclic carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT; GORECZNY GREGORY
权利人:NIROGY THERAPEUTICS INC
摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.