CAS: 437-82-1; 2,6-Difluoroanisole

相似化合物

452-10-8 321-28-8 2324-98-3

上下游产品

CAS号28177-48-2 2,6-二氟苯酚 | CAS号74-88-4 碘甲烷 | CAS号186581-53-3 重氮甲烷 | CAS号437-83-2 3-氟-2-甲氧基苯胺 | CAS号484-94-6 2-氟-6-硝基苯甲醚 | CAS号1489-53-8 1,2,3-三氟苯 | CAS号363-47-3 3,5-二氟-4-甲氧基苯胺 | CAS号392-25-6 2,6-二氟-4-硝基苯甲醚 | CAS号28177-48-2 2,6-二氟苯酚 | CAS号170570-79-3 3',5'-二氟-4'-甲氧基苯乙酮 | CAS号178974-97-5 2,4-二氟-3-甲氧基苯甲酸 | CAS号443-42-5 3,5-二氟-4-甲氧基苯酚

1,3-二氟苯置于过氧乙酸,正丁基锂,碳酸氢钠体系中,用 四氢呋喃,2-甲基四氢呋喃,乙醚,正己烷,水 作为反应溶剂,化学反应 34.0H,反应生成 2,6-二氟苯甲醚
参考文献:1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹 啉-3-羧酸的合成方法
标题:1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹 啉-3-羧酸的合成方法
摘要:本发明公开了一种1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法,包括以下反应步骤:间二氟苯与有机锂试剂反应,得到的芳基锂中间体与硼酸酯反应,经淬灭,得到2,6-二氟苯硼酸及2,6-二氟苯硼酸酯,经氧化得到的2,6-二氟苯酚与甲基化试剂反应,得到的2,6-二氟苯甲醚与有机锂试剂反应,得到相应的芳基锂中间体与二氧化碳反应,得到的产物再与酰氯化试剂反应,得到2,4-二氟-3-甲氧基苯甲酰氯,然后经关环反应,水解反应等,得到1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸.本发明具有原料易得,各步反应收率好,原子经济性高,适合工业化应用等优点.

专利信息

专利号:US-2017342077-A1
优先权日:2016-05-24
标题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n n n n n n n n n n wherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.

专利号:WO-2017205539-A1
优先权日:2016-05-24
标 题 :Diazene directed modular synthesis of compounds with quaternary carbon centers

专利号:US-11213031-B2
优先权日:2017-11-13
标 题:Tetrazolylpropyl derivatives and their use as fungicides
发明人：SUDAU ALEXANDER; HOFFMANN SEBASTIAN; DAHMEN PETER; WEBSTER ROBERT ALAN; MEISSNER RUTH; GOERTZ ANDREAS; MILLER RICARDA; COQUERON PIERRE-YVES; BERNIER DAVID; NICOLAS LIONEL; BRUNET STEPHANE; KENNEL PHILIPPE; TOQUIN VALERIE; GOURGUES MATHIEU; LOQUE DOMINIQUE; THOMAS VINCENT
权利人:BAYER AG; BAYER CROPSCIENCE AG
摘要:The present invention relates to tetrazolylpropyl derivatives of formula (I) n nwherein one of V 1 and V 2 represents CR 3 and the other one of V 1 and V 2 represents N, Q represents a 6-membered aromatic cycle as defined in the specification, and R 1 , R 2 , R 3 , R 4 , and R 5 are defined as disclosed in the specification, to compositions comprising such compounds, to the use of said compounds as fungicides, as well as to particular intermediates useful in the synthesis of said tetrazolylpropyl derivatives.

专利号:US-8946422-B2
优先权日:2005-07-27
标题:8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
发明人：BRADBURY BARTON JAMES; WILES JASON ALLAN; WANG QIUPING; HASHIMOTO AKHIRO; LUCIEN EDLAINE; PAIS GODWIN CLARENCE GILROY; DESHPANDE MILIND; PUCCI MICHEAL JOHN; KIM HA YOUNG
权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; WANG QIUPING; HASHIMOTO AKHIRO; LUCIEN EDLAINE; PAIS GODWIN CLARENCE GILROY; DESHPANDE MILIND; PUCCI MICHEAL JOHN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC
摘要:The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

专利号:CN-111377826-A
优先权日:2020-03-23
标 题 :A kind of green synthesis process of quinolone key intermediate

专利号:WO-2024068976-A1
优先权日:2022-09-29
标 题 :Azole derivatives as shp2 inhibitors
发明人：PETROCCHI ALESSIA; MONTALBETTI CHRISTIAN; DI FABIO ROMANO; CIAMMAICHELLA ALINA; ROSSETTI ILARIA
权利人:IRBM S P A; C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING
摘要:The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase. Compounds of the invention can be used for the treatment of disorders associated with SHP2 deregulation. The present invention also relates to pharmaceutical compositions containing said compounds and to their method of synthesis.