CAS: 341-23-1; 4-Fluoro-1H-Indazole

上下游产品

4-氟-1H-吲唑-3-甲醛 4-Fluoro-1H-Indazole-3-Carbaldehyde 518987-93-4

3-氟-2-甲基苯胺置于tetrafluoroboric Acid,Sodium Nitrite,18-冠醚-6,Potassium Acetate体系中,用 水,氯仿 作为反应溶剂,化学反应生成 4-氟-1H-吲唑
参考文献:4-Substituted Indazoles As New Inhibitors Of Neuronal Nitric Oxide Synthase
标题:4-Substituted Indazoles As New Inhibitors Of Neuronal Nitric Oxide Synthase
摘要:A Series Of Halo-1-H-Indazoles Has Been Synthesized And Evaluated For Its Inhibitory Activity On Neuronal Nitric Oxide Synthase. Introduction Of Bromine At The C4 Position Of The Indazole Ring System Provided A Compound Almost As Potent As The Reference Compound,That Is,7-Nitroindazole (7-Ni). The Importance Of Position 4 Is Further Demonstrated By The Synthesis And Pharmacological Evaluation Of The 4-Nitroindazole Which Was Also A Potent Inhibitor Of Nos Activity. These Compounds Also Exhibited In Vivo Nos Inhibitory Activity,As Attested By Potent Antinociceptive Effects Following Systemic Administration. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2007.03.024

专利信息

专利号:US-12428380-B2
优先权日:2023-06-28
标 题 :Compounds
发明人：BANISTER SAMUEL; JORGENSEN WILLIAM; TAN JINLONG; WHISH LACHLAN
权利人:Psylo Pty Ltd
摘要:The present disclosure relates generally to compounds, their methods of synthesis, and their use in the treatment of mental illness or central nervous system disorders.