专利号:US-2024158926-A1 优先权日:2022-11-03 标 题 :Electrochemical synthesis of hydroxyvaleric acid from levulinic acid 发明人:HOLEWINSKI ADAM; DE SOUZA LUCAS FRANCISCO WILLIAN 权利人:UNIV COLORADO REGENTS 摘要:Disclosed herein are methods of electrochemical synthesis of hydroxyvaleric acid from levulinic acid. For example, disclosed herein are methods comprising electrochemical synthesis of hydroxyvaleric acid from levulinic acid, wherein the method is conducted in an electrochemical cell wherein a working electrode is in electrochemical contact with an aqueous electrolyte and levulinic acid, wherein the method comprises applying a potential to electrochemically reduce the levulinic acid to form hydroxyvaleric acid. Also disclosed herein are methods of synthesizing gamma-valerolactone from hydroxyvaleric acid, the method comprising acid-catalyzed esterification. Also disclosed herein are methods of use of the products produced by any of the methods herein.
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-5753726-A 优先权日:1995-12-20 标 题:Synthesis of modified epoxy resins for cathodic electrodeposition with catalyst deactivation and diol modification 发明人:REUTER HARDY; JOUCK WALTER; OTT GUENTHER 权利人:BASF LACKE & FARBEN 摘要:Epoxy resins for preparing water-dispersible binders for cathodic electrodeposition coating materials, the epoxy resin being preparable by reacting a) polyepoxides having at least one glycidyl group per molecule b) and, optionally, up to 60% by weight, based on the overall epoxy resin reaction product, of aliphatic and/or alicyclic hydroxy compounds having preferably two or on average less than two hydroxyl groups per molecule and a molecular weight of less than 9000 g/mol, c) in the presence of a catalyst consisting of neutral metal salts, such as alkali metal salts and alkaline earth metal salts, zinc salts and nickel salts of tetrafluoroboric, tetrachloroboric, hexafluoro- antimonic,hexachloroantimonic,hexafluorophosphoric, perchlorate and periodic acid, and d) adding a deactivating agent which prevents the epoxy groups reacting further or effectively reduces the rate of such reaction as soon as the phenolic hydroxyl groups have already substantially reacted and at least 0.6% by weight of epoxy groups are still present, based on the overall weight of the epoxy resin reaction product.\\!
专利号:US-11629137-B2 优先权日:2017-04-24 标 题:Methods of manufacturing of niraparib 发明人:STEWART ALISTAIR; TOTO ANTHONY JOSEPH; CHEN FRANK XING; WU GEORGE 权利人:TESARO INC 摘要:Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.
专利号:US-6136229-A 优先权日:1998-10-15 标题 :Method for the mechanochemical preparation of high performance ceramics 发明人:CUI CHANGXING; SU JI; BAUGHMAN RAY H 权利人:ALLIED SIGNAL INC 摘要:Disclosed are mechanochemical processes for the synthesis of high performance electroceramics from organometallic precursors, and compositions resulting from the processes.
专利号:WO-2008044544-A1 优先权日:2006-10-04 标题 :Fine particle of hydroxide and/or oxide and process for producing the same 发明人:HORIGUCHI SHINICHI; ARIZONO JYUNICHI; OOSHIMA YASUHIRO 权利人:NISSHIN SPINNING; HORIGUCHI SHINICHI; ARIZONO JYUNICHI; OOSHIMA YASUHIRO 摘要:Fine particles of a hydroxide and/or oxide which are produced by electrodialysis; and a process for producing the fine particles. A conductive liquid which is a poor solvent for the hydroxide and/or oxide to be generated in a synthesis chamber is used as a synthesis-chamber liquid. The synthesis chamber is used in combination with a desalting chamber separated from the synthesis chamber by a cation-exchange membrane, the desalting chamber being filled with an aqueous electrolyte solution containing metal ions as a raw material for the hydroxide and/or oxide. A voltage not lower than the theoretical water electrolysis voltage is applied to the chambers. The fine hydroxide and/or oxide particles, which are produced through electrodialysis, are reduced in equipment cost and production cost.
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