CAS: 17676-24-3; (S,E)-4,4'-(Penta-1,4-Diene-1,3-Diyl)Diphenol

上下游产品

(E)-1,3-bis(4-[tetrahydro-2H-pyran-2-yloxy]phenyl)pent-4-en-1-ol 4-coumaryl 4-coumarate (+)-(S)-tetrahydrohinokiresinol

📜(3S)-4''-O-β-D-Glucopyranosylhinokiresinol置于盐酸,水体系中,化学反应 2.0H,反应生成葡萄糖,反式-异扁柏脂素
参考文献:Four New Norlignan Glycoside Isomers From The Twigs Of Cephalotaxus Oliveri Mast.
标题:Four New Norlignan Glycoside Isomers From The Twigs Of Cephalotaxus Oliveri Mast.
摘要:Four Novel Isomers Of Norlignan Glycoside Were Isolated From Cephalotaxus Oliveri Mast.. Their Structures Were Elucidated As 3S-4 ''-O-Beta-D-Glucopyranosylnyasol 1,3S-4'-O-Beta-D-Glucopyranosylnyasol 2,3S-4 ''-O-Beta-D-Glucopyranosylhinoldresinol 3,3S-4'-O-Beta-D-Glucopyranosylhinokiresinol 4 By Extensive Spectroscopic Methods Including I D And 2D NMR Experiments (H-1,C-13,Dept,H-1-H-1 Cosy,Hsqc,Hmbc,Roesy) Along With Hr-Esims And Comparison To Literature Data. Their Absolute Configurations Were Elucidated Through Cd Spectra Coupled With The Quantum Chemical Cd Calculations. (C) 2017 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2017.10.017

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.