CAS: 155742-64-6; Methyl 2-(2-Chloro-1-Iminoethyl)Hydrazinecarboxylate

相似化合物

155764-79-7 159016-21-4 851535-08-5

氯化氰 反应生成2-(2-氯-1-亚乙基)酰肼甲酸甲酯
参考文献:Morpholine Compounds Are Prodrugs Useful As Tachykinin Receptor
标题:Morpholine Compounds Are Prodrugs Useful As Tachykinin Receptor
摘要:通用结构式为:##str1## 的替代杂环是一种在治疗炎症性疾病,疼痛或偏头痛,哮喘和呕吐方面有用的tachykinin受体拮抗剂.

专利信息

专利号:US-6407255-B2
优先权日:1998-06-16
标题:Chemical synthesis of 1,2,4-triazolinone derivative
发明人：COTTRELL IAN FRANK; DOLLING ULF H; HANDS DAVID; WILSON ROBERT DARRIN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.

专利号:US-8940890-B2
优先权日:2010-05-24
标 题:Preparation method of 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3(S)-4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one
发明人：JI JIANXIN; ZHANG QIANG; DU FENGTIAN; JIN YI; ZHANG TAO; GUO NA; YAN XIAOWEI; YANG YONGRONGN; LI BOGANG
权利人:JI JIANXIN; ZHANG QIANG; DU FENGTIAN; JIN YI; ZHANG TAO; GUO NA; YAN XIAOWEI; YANG YONGRONGN; LI BOGANG; CHENGDU DI AO PHARMACEUTICAL GROUP CO LTD
摘要:Disclosed is a synthesis method of a compound of formula 1,5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxyl]-3(S)-4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one (i.e. aprepitant), which comprises cyclizing a compound of formula 4 in a solvent, wherein R is C 1 -C 5 alkyl. The intermediate for preparing aprepitant is also disclosed. The present method is especially suitable for industrial production of aprepitant.

专利号:US-2002019524-A1
优先权日:1998-06-16
标题 :Chemical synthesis of morpholine derivatives

专利号:US-6297376-B1
优先权日:1998-06-16
标题 :Chemical synthesis of morpholine derivatives