📜(E)-1-(Phenylseleno)-2-(P-Tolylsulfonyl)Ethene Se-Oxide 以 氯仿,苯 用作溶剂,化学反应 5.0H,以51%的收率获得乙炔基对甲苯基砜 参考文献:Selenosulfonation Of Acetylenes: Preparation Of Novel .Beta.-(Phenylseleno)Vinyl Sulfones And Their Conversion To Acetylenic And .Beta.-Functionalized Sulfones 标题:Selenosulfonation Of Acetylenes: Preparation Of Novel .Beta.-(Phenylseleno)Vinyl Sulfones And Their Conversion To Acetylenic And .Beta.-Functionalized Sulfones 摘要: Doi:10.1021/jo00166A030
专利号:US-6384228-B2 优先权日:1998-05-26 标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof 发明人:NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO 权利人:NIHON MEDIPHYSICS CO LTD 摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-2003082830-A1 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-2002010339-A1 优先权日:1998-05-26 标 题:Method for synthesis of halopyridyl-acyclopentane derivative and intermediate thereof
专利号:WO-0006525-A9 优先权日:1998-07-25 标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A2 优先权日:1998-07-25 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
[参考文献]: Elena Petit, Et Al. Tosvinyl And Besvinyl As Protecting Groups Of Imides, Azinones, Nucleosides, Sultams, And Lactams. Catalytic Conjugate Additions To Tosylacetylene. J Org Chem. 2014 Sep 19;79(18):8826-34. [参考文献]: Takeshi Hanazawa, Et Al. Efficient And Practical Method For Synthesizing Optically Active Indan-2-Ols By The Ti(O-I-Pr)(4)/2 I-Prmgcl-Mediated Metalative Reppe Reaction. J Org Chem. 2003 Jun 13;68(12):4980-3.
合成参考文献
摘要:Shinmyozu, T.; Shibahara, M., Science of Synthesis, (2010) 45, 1305. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 54. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 34. 摘要:Udmark, J.; Brøndsted Nielsen, M., Science of Synthesis Knowledge Updates, (2014) 3, 362. 摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 302.