CAS: 136-44-7; Lisadimate

📜Glycerol Mono-P-Nitrobenzoate置于palladium On Activated Charcoal,乙酸乙酯体系中,化学反应生成利沙地酯
参考文献:Van Lohuizen; Verkade,Recueil Des Travaux Chimiques Des Pays-Bas,1959,Vol. 78,P. 460,462
标题:Van Lohuizen; Verkade,Recueil Des Travaux Chimiques Des Pays-Bas,1959,Vol. 78,P. 460,462

专利信息

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-9757317-B2
优先权日:2014-09-12
标题 :Cosmetic compositions and methods for inhibiting melanin synthesis
发明人：LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR
权利人:PROCTER & GAMBLE
摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

专利号:US-9498420-B2
优先权日:2013-05-01
标 题:Cosmetic compositions and methods for inhibiting melanin synthesis
发明人：LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; TANAKA SHUHEI
权利人:PROCTER & GAMBLE
摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

专利号:US-6649751-B2
优先权日:1992-05-14
标 题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：USMAN NASSIM; WINCOTT FRANCINE; SWEEDLER DAVID; BEIGELMAN LEONID; DUDYCZ LECH W; GRIMM SUSAN; DIRENZO ANTHONY; TRACZ DANUTA
权利人:SIRNA THERAPEUTICS INC
摘要:Provided is a method for purification and synthesis of RNA molecules that have at least one chemical modification.

专利号:US-7041817-B2
优先权日:1992-05-14
标题:Synthesis, deprotection, analysis and purification of RNA and ribozymes
发明人：USMAN NASSIM; WINCOTT FRANCINE; SWEEDLER DAVID; BEIGELMAN LEONID; DUDYCZ LECH W; GRIMM SUSAN; DIRENZO ANTHONY; TRACZ DANUTA
权利人:SIRNA THERAPEUTICS INC
摘要:Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.