CAS: 13093-04-4; N1,N6-Dimethylhexane-1,6-Diamine

相似化合物

1013915-06-4 35161-70-7 2439-54-5

上下游产品

N,N'-dimethyl-N,N'-hexanediyl-bis-benzenesulfonamideN,N'-dimethyl-N,N'-hexanediyl-bis-benzenesulfonamide 1,N2-dibenzylidenehexane-1,6-diamineN1,N2-dibenzylidenehexane-1,6-diamine dimethyl sulfate 1 ,6-dibromohexaneN,N'-dimethyl-N,N'-hexanediyl-bis-carbamoyl chlorideN,N'-dimethyl-N,N'-hexanediyl-bis-carbamoyl chloride N,N''-1,6-(hexanediyl)bis[N'-cyclohexyl-N'-[(cyclohexylimino)(4-morpholinyl)methyl]-N-methylurea] N-Benzyloxy-3-({6-[(2-benzyloxycarbamoyl-ethyl)-methyl-amino]-hexyl}-methyl-amino)-propionamide piperidine

1,6-二(叔-丁氧羰基氨基)己烷置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应生成N,N'-二甲基-1,6-己二胺
参考文献:In Vitro Cytotoxicity On Human Ovarian Cancer Cells By T-Type Calcium Channel Blockers
标题:In Vitro Cytotoxicity On Human Ovarian Cancer Cells By T-Type Calcium Channel Blockers
摘要:The Growth Inhibition Of Human Cancer Cells Via T-Type Ca2+ Channel Blockade Has Been Well Known. Herein,A Series Of New 3,4-Dihydroquinazoline Derivatives Were Synthesized Via A Brief Sar Study On Kys05090 Template And Evaluated For Both T-Type Ca2+ Channel (Ca(V)3.1) Blockade And Cytotoxicity On Three Human Ovarian Cancer Cells (Sk-Ov-3,A2780 And A2780-T). Most Of Compounds Except 6I Generally Exhibited More Potent Cytotoxicity On Sk-Ov-3 Than Mibefradil As A Positive Control Regardless Of The Degree Of T-Type Channel Blockade. In Particular,Eight Compounds (Kys05090,6A And 6C-6H) Showing Strong Channel Blockade Exhibited Almost Equal And More Potent Cytotoxicity On A2780 When Compared To Mibefradil. On A2780-T Paclitaxel-Resistant Human Ovarian Carcinoma,Two Compounds (Kys05090 And 6D) Were 20-Fold More Active Than Mibefradil. With Respect To Cell Cycle Arrest Effect On A2780 And A2780-T Cells,Kys05090 Induced Large Proportion Of Sub-G(1) Phase In The Cell Cycle Progression Of A2780 And A2780-T,Meaning The Induction Of Cancer Cell Death Instead Of Cell Cycle Arrest Via Blocking T-Type Ca2+ Channel. Among New Analogues,Compounds 6G And 6H Induced Cell Cycle Arrest At G(1) Phase Of A2780 And A2780-T Cells In Dose-Dependent Manner And Exhibited Strong Anti-Proliferation Effects Of Ovarian Cancer Cells By Blocking T-Type Ca2+ Channel. Furthermore,6G And 6H Possessing Strong Cytotoxic Effects Could Induce Apoptosis Of A2780 Cells,Which Was Detected By Confocal Micrographs Using Dapi Staining. (C) 2013 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2013.10.049

专利信息

专利号:US-5139940-A
优先权日:1989-10-26
标题 :Activation compounds and methods of synthesis of activation compounds
发明人：ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W
权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W
摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

专利号:US-4472568-A
优先权日:1981-11-12
标 题:Process for the preparation of polyamines from N-monoaryl-N',N'-dialkyl urea compounds and their use for the synthesis of polyurethanes
发明人：RASSHOFER WERNER; GROEGLER GERHARD
权利人:BAYER AG
摘要:This invention relates to an improved process for the preparation of aromatic polyamines containing urethane and/or biuret and/or urea and/or isocyanurate groups and preferably also ether groups by the hydrolysis of poly-N-monoaryl-N',N'-dialkyl urea compounds (1-aryl-3,3-dialkyl ureas). The ureas are obtained by the reaction of secondary aliphatic, cycloaliphatic or saturated heterocyclic amines with divalent to tetravalent isocyanate compounds containing isocyanate end groups attached to aromatic residues. The ureas correspond to the general formula: wherein R1, R2 denote alkyl or cycloalkyl groups, or together form a ring and A denotes a divalent to tetravalent residue attached to the ureas by aromatic groups. Hydrolysis is carried out in the presence of water and up to two equivalents of a base containing hydroxide ions and/or up to two equivalents of a compound containing tertiary amino groups, optionally in the presence of solvents. The use of the polyamines obtained by this process for the synthesis of polyurethanes is also described.

专利号:EP-0915897-B1
优先权日:1996-06-25
标 题 :Process for combining parallel oligonucleotide synthesis and preparation of oligomer chips
发明人：WEILER JAN; HOHEISEL JOERG
权利人:DEUTSCHES KREBSFORSCH
摘要:The invention concerns a process for the parallel synthesis of oligonucleotides on an alkylamino-modified matrix surface, characterized in that 3-succinate derivatives of protected nucleosides are applied thereto and oligonucleotide synthesis takes place by means of automated DNA synthesis. The invention also concerns the use of the oligomer chip formed in the process.

专利号:US-5936077-A
优先权日:1996-07-11
标 题:Solid phase synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BEIER MARKUS
权利人:HOECHST AG
摘要:A process is described for preparing oligonucleotides by solid phase synthesis in which exocyclic amino groups present on nucleobases are protected with cyclic diacyl groups, which can be deprotected in the presence of a strong, nonnucleophilic base. Novel intermediates employing the cyclic diacyl protecting groups are also described.

专利号:US-5087691-A
优先权日:1989-09-01
标题 :Poly-phenylated diamines and their use as polycondensation monomers in the synthesis of polyamide, poly(amide-imide), and polyimide polymers
发明人：HARRIS FRANK W
权利人:UNIV AKRON
摘要:New polyphenylated polynuclear aromatic diamines, such as 1,3-bis[4-aminophenyl]-2,3,5-triphenylbenzene, a process for their manufacture and their use as polycondensation components for the manufacture of polyamide, polyamide-imide and polyimide polymers are described. The polymers obtained with the aromatic diamines according to the invention are readily soluble, rigid-rod polymers and are distinguished by outstanding modulus, tensile compression strength, energy absorption, coefficient of expansion and electrical properties.

专利号:EP-2738198-A1
优先权日:2012-11-29
标题:Enzymatic synthesis of polyamide in aqueous mini-emulsion
发明人：DR ANDREAS TADEN; Dr Ito Kenji; PROF DR KATHARINA LANDFESTER
权利人:HENKEL AG & CO KGAA; MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V
摘要:A process for preparing an aqueous polyamide dispersion, said process comprising reacting in an aqueous medium: a) an organic diamine compound (A) and b) an organic dicarboxylic acid compound (B), in the presence of c) at least one hydrolase enzyme (C) which catalyzes a polycondensation reaction of the diamine compound (A) and dicarboxylic acid compound (B) and d) an emulsifier (D), said process being characterized in that at least a fraction of the diamine compound (A) and the dicarboxylic acid compound (B) are provided in the aqueous medium as a disperse phase having an average droplet diameter of from 40 to 500nm.