CAS: 120511-92-4; 2,2'-(5-((4H-1,2,4-Triazol-4-yl)Methyl)-1,3-Phenylene)Bis(2-Methylpropanenitrile)

相似化合物

112809-27-5 1249332-95-3 36175-43-6

上下游产品

1,2,4-Triazole α,α,α',α'-tetramethyl-5-chloromethyl-1,3-benzene diacetonitrile sodium triazole 2-[3-bromomethyl-5-(cyanodimethylmethyl)phenyl]-2-methylpropanenitrile

专利信息

专利号:US-2006035950-A1
优先权日:2004-08-09
标 题:Novel processes for preparing substantially pure anastrozole
发明人：ALNABARI MOHAMMED; FREGER BORIS; ARAD ODED; ZELIKOVITCH LIOR; SERYI YANA; DANON EDNA; DAVIDI GUY; KASPI JOSEPH
权利人:ALNABARI MOHAMMED; FREGER BORIS; ARAD ODED; ZELIKOVITCH LIOR; SERYI YANA; DANON EDNA; DAVIDI GUY; KASPI JOSEPH
摘要:The present invention provides novel processes for purifying anastrozole, devoid of using liquid chromatography. The purification processes are via the isolated anastrozole salt forms, either by crystallization or by selective acidic extractions, and optionally in both cases, converting the purified anastrozole salt to anastrozole base. Also provided is an improved process for the synthesis of anastrozole, which is obtained by alkylating the isolated and purified starting material 3,5-bis(2-cyanoprop-2-yl)benzylbromide, the process being devoid of using toxic, hazardous and environmental unfriendly solvents and reagents.