CAS: 111-57-9; N-(2-Hydroxyethyl)Stearamide

该化合物是来自石酸和2-氢氧乙胺的氨化物,该化合物一般是白色的,是白色的固体或蜡状物质,其特点是长期的氢氟碳氢化合物链,具有表面活性特性,并存在一种增强极溶溶剂溶解度的氢氧乙基盐类.N-(2-氢氧乙基)沙丁胺酯因其乳化,增厚和稳定性而闻名,使其在各种应用中有用,包括化妆品,个人护理产品和工业配方.它具有良好的热稳定性,可在各种pH值环境中有效发挥作用.此外,该化合物一般认为毒性较低,但安全数据应始终用于具体的处理和使用准则.其独特的结构使其能够与水生物质和水离水物质相互作用,使其成为化学配制的多种成分.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号141-43-5 2-氨基乙醇 | CAS号57-11-4 硬脂酸 | CAS号111-63-7 硬脂酸乙烯酯 | CAS号112-76-5 十八碳酰氯 | CAS号14464-32-5 N-羟基琥珀酰亚胺硬酯酸酯 | CAS号111-61-5 硬脂酸乙酯 | CAS号10287-60-2 2-aminoethyl st... | CAS号7596-88-5 N-月桂酰甘氨酸 | CAS号14246-55-0 N-肉豆蔻酰甘氨酸 | CAS号2441-41-0 棕榈酰甘氨酸 | CAS号6333-54-6 硬脂酰甘氨酸 | CAS号14246-53-8 辛酰甘氨酸 | CAS号22024-22-2 2-aminoethyl °C... | CAS号10287-60-2 2-aminoethyl st... | CAS号31314-15-5 2-(°Ctadecylami... | CAS号14351-40-7 硬脂酸2-[(1-十八烷酰基)氨基]乙脂

合成工艺路线路线简述

  • 合成目标产物 Stearoyl Ethanolamide 主要起始原料 Monoethanolamine And Octadecanamide
  • (文献来源)合成步骤主要原料 Monoethanolamine 和 Octadecanamide
2-氨基乙基硬脂酸酯 反应生成硬脂酰胺mea
参考文献:Desnuelle; Naudet; Sambuc,Bulletin De La Societe Chimique De France,1949,P. 651
标题:Desnuelle; Naudet; Sambuc,Bulletin De La Societe Chimique De France,1949,P. 651

海关参考信息

专利信息


专利号:US-2024309142-A1
优先权日:2023-03-17
标题 :Capped block copolymers, their synthesis, manufacture, and methods of use
发明人:MAN VICTOR FUK-PONG; LI XIAOJIN HARRY; CHEN YIQING; PU GANG; HUNT JR CLINTON
权利人:ECOLAB USA INC
摘要:This disclosure relates to capped block copolymers, preferably reverse block copolymers capped with a hydrophobic group. Preferred hydrophobic groups include benzyl groups and silyl groups. In a preferred embodiment, the reverse block copolymer has at least two arms, wherein each arm is capped with a hydrophobic group. The disclosure also provides for the synthesis of the capped block copolymers as well as methods of using the capped block copolymers for defoaming and antifoaming applications.

专利号:WO-2005079742-A1
优先权日:2004-02-19
标 题:Cosmetic and/or dermatological agent for increasing the endogenous lipid content of the skin
发明人:VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE
权利人:STOCKHAUSEN CHEM FAB GMBH; VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE
摘要:The invention relates to the use of at least one active ingredient that is selected from the water-soluble groups: (a) allantoin; (b) salts and/or esters of gluconic acid and/or aspartic acid; (c) precursors of creatine, creatine and creatinine and their derivatives; (d) glycyrrhetinic acid or the salts and/or esters thereof; (e) D-panthenol and/or at least one active ingredient that is selected from the oil-soluble groups: (f) vitamin E acetate; (g) cholesterol; (h) derivatives of glycyrrhetinic acid, in so far as they are soluble in the oils and fats that are conventionally used in the cosmetic industry; (i) vegetable oils and fats; (j) non-saponifiable fractions of vegetable fats. Said active ingredients are used alone or in combination with one or more active ingredients from the groups (a) to (j) to produce a cosmetic and/or dermatological agent for stimulating the endogenous synthesis of barrier substances, in particular for increasing the endogenous lipid content of the skin.

专利号:US-9522192-B2
优先权日:2012-12-13
标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides
发明人:CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE
权利人:EPITECH GROUP SRL
摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

专利号:US-2023346952-A1
优先权日:2015-09-22
标题:Cannabinoid glycoside prodrugs and methods of synthesis
发明人:ZIPP BRANDON J; HARDMAN JANEE’ M; BROOKE ROBERT T; DEUTSCHER TYREL R
权利人:GRAPHIUM BIOSCIENCES INC
摘要:The present invention provides tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs and pharmaceutical compositions comprising these compounds, and their use for the site-specific delivery of tetrahydrocannabinol or cannabidiol. Also provided are processes for the preparation of purified tetrahydrocannabinol glycoside and cannabidiol glycoside prodrugs.

专利号:EP-3842443-B1
优先权日:2013-03-15
标 题 :Methods for the synthesis of sphingomyelins and dihydrosphingomyelins

专利号:EP-2885416-B1
优先权日:2012-08-20
标 题 :Large scale enzymatic synthesis of oligosaccharides
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主要参考文献


1: Dubuc I, Prunier J, Lacasse É, Gravel A, Puhm F, Allaeys I, Archambault AS, Gudimard L, Villano R, Droit A, Flamand N, Boilard É, Flamand L. Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice. Front Immunol. 2022 Jun 24;13:893792. doi: 10.3389/fimmu.2022.893792.
2: Chiurchiù V, Leuti A, Smoum R, Mechoulam R, Maccarrone M. Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes. FASEB J. 2018 Oct;32(10):5716-5723. doi: 10.1096/fj.201800107R. Epub 2018 Jun 7. BioBank Japan Project; Inohara H, Murakami Y, Matsuda K, Okada Y, Yamauchi T, Kadowaki T. Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes. Commun Med (Lond). 2023 Jan 9;3(1):5. doi: 10.1038/s43856-022-00231-3.
4: Alarcón-Yaquetto DE, Caballero L, Gonzales GF. Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders. High Alt Med Biol. 2017 Dec;18(4):322-329. doi: 10.1089/ham.2016.0148. Epub 2017 Jun 30.

合成参考文献


摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
摘要:
摘要:Final Report 8/1995 Available from CIR
摘要:International Journal of Toxicology 34(Suppl.1):18-34, 2015
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