CAS: 1093072-86-6; 1-(3-Dimethylamino-Propyl)-1-Phenyl-1,3-Dihydro-Isobenzofuran-5-Carbonitrile Oxalate

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1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile oxalic acid

📜1-(3-Dimethylamino-Propyl)-1-Phenyl-1,3-Dihydro-Isobenzofuran-5-Carbonitrile,草酸 以 丙酮 用作溶剂,以0.19 G的收率获得外消旋去氟西酞普兰草酸盐
参考文献:From The Selective Serotonin Transporter Inhibitor Citalopram To The Selective Norepinephrine Transporter Inhibitor Talopram: Synthesis And Structure−activity Relationship Studies
标题:From The Selective Serotonin Transporter Inhibitor Citalopram To The Selective Norepinephrine Transporter Inhibitor Talopram: Synthesis And Structure−activity Relationship Studies
摘要:Citalopram And Talopram Are Structurally Closely Related,But They Have Very Distinct Pharmacological Profiles As Selective Inhibitors Of The Serotonin And Norepinephrine Transporters,Respectively. A Systematic Structure-Activity Relationship Study Was Performed,In Which Each Of The Four Positions Distinguishing The Two Compounds Were Varied. The Inhibitory Potencies Of The Resulting 16 Compounds Were Tested At Both Serotonin And Norepinephrine Transporters. This Showed That Particularly Two Of The Four Positions Are Determinants For The Biological Activity.
Doi:10.1021/jm701602G