CAS: 10444-89-0; 2-Amino-5-Trifluoromethyl-1,3,4-Thiadiazole

相似化合物

25306-15-4 108-33-8 312524-33-7

上下游产品

CAS号79-19-6 硫代氨基脲 | CAS号407-25-0 三氟乙酸酐(TFAH) | CAS号76-05-1 三氟乙酸(TFA) | CAS号4005-51-0 2-氨基-1,3,4-噻二唑 | CAS号2926-29-6 三氟代甲烷亚磺酸钠 | CAS号2314-97-8 三氟碘甲烷 | CAS号354-32-5 三氟乙酰氯 | CAS号37461-61-3 2-溴-5-三氟甲基-1,3,4-噻唑 | CAS号25366-20-5 1-methyl-3-[5-(... | CAS号27603-12-9 2,2,2-trichloro... | CAS号26816-20-6 1-(2-chloroethy... | CAS号27603-11-8 2,2-dichloro-N-... | CAS号27603-23-2 2,2,2-trifluoro... | CAS号1885-14-9 氯甲酸苯酯 | CAS号53645-98-0 2-氯-5-三氟甲基-(1,3... | CAS号42458-71-9 2-氯-n-(5-三氟甲基-[... | CAS号50830-58-5 2-is°Cyanato-5-...

📜2-(2,2,2-Trifluoroethylidene)Hydrazine-1-Carboximidothioic Acid置于iron(III) Chloride体系中,化学反应生成2-氨基-5-三氟甲基-1,3,4-噻二唑
参考文献:新型短效催眠药hie-124的噻二唑[3,2-A ] [1,3]二氮杂analogue类似物的合成,生物学评价和分子建模研究
标题:新型短效催眠药hie-124的噻二唑[3,2-A ] [1,3]二氮杂analogue类似物的合成,生物学评价和分子建模研究
摘要:合成了一系列新的6,7-二氢-[1,3,4]噻二唑[3,2-A ] [1,3]二氮杂analogue类似物,并对其进行了生物学评估.与硫喷妥钠(6)相比,化合物gs-62(33)表现出强大的体内短效催眠活性,其起效时间,睡眠时间和治疗指数分别为6.4+/-0.2,94.8+/-5.3分钟,6.62 .维持剂量为6时,化合物33没有显示出任何急性耐受的迹象.同时33增强了6的体内催眠作用等摩尔量(0.06 Mmol)的组合分别显示起效和持续时间分别为7.5+/-1.3,62.5+/-5.9分钟.这种组合允许使用较低剂量的两种药物,以避免不良的副作用.对接研究揭示了非常好的相互作用和与gaba A受体的bdz结合位点的结合,尤其是与arg87,Arg149和thr151氨基酸残基的结合.
Doi:10.1016/j.Ejmech.2016.08.038

专利信息

专利号:US-4412079-A
优先权日:1968-03-13
标题:Thiadiazole compounds and methods of using said compounds in agriculture
发明人：CEBALO TONY; WALDE ROBERT A
权利人:AIR PROD & CHEM
摘要:Novel thiadiazole compounds are disclosed which contain in the 5 position, C-linked moieties which are either acyclic hydrocarbon radicals or halogenated acyclic hydrocarbon radicals (in which case each halogen is independently selected from F, Cl and Br). These novel compounds also contain an exocyclic nitrogen in the 2 position, and some of them contain the exocyclic substituent: wherein R3 is a lower acyclic hydrocarbon radical and R4 is either H or a lower acyclic hydrocarbon radical. Synthesis of these compounds is disclosed, including synthesis of those which exhibit isomerism and/or tautomerism. Various of these compounds have various agricultural utilities (e.g. as herbicides, insecticides, acaricides and fungicides), each of them having at least one such biological utility. Methods of using these compounds in phytotoxic fungicidal, acaricidal and insecticidal applications are disclosed.

专利号:US-6743811-B2
优先权日:1999-07-28
标 题:Oxazalidinone compounds and methods of preparation and use thereof
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; GADWOOD ROBERT C
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-8318928-B2
优先权日:2008-12-15
标题 :Fused imidazole carboxamides as TRPV3 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
权利人:CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI; GLENMARK PHARMACEUTICALS SA
摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.