📜Magnesium,Pentane,Chloride置于pd-Baso4,乙醚,氨,Sodium Amide,乙酸乙酯体系中,化学反应生成顺-3-壬烯-1-醇 参考文献:Paul; Tchelitcheff,Bulletin De La Societe Chimique De France,1956,P. 869,874 标题:Paul; Tchelitcheff,Bulletin De La Societe Chimique De France,1956,P. 869,874
专利号:US-10202620-B2 优先权日:2014-05-16 标 题:Synthesis of olefinic alcohols via enzymatic terminal hydroxylation 发明人:COELHO PEDRO; CHEN MIKE M Y; MEINHOLD PETER; CHO CATHERINE MEE-HIE; BUI VU; HEEL THOMAS 权利人:PROVIVI INC 摘要:In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.
专利号:BR-112018009885-B1 优先权日:2015-11-18 标题:METHODS OF SYNTHESIS OF FATTY OLEFIN DERIVATIVE THROUGH OLEFIN METATHESIS
专利号:WO-2024230844-A1 优先权日:2023-05-11 标 题:Cationic lipids and preparation method thereof 发明人:MASHIACH ROI 权利人:RIBOX THERAPEUTICS HK LTD 摘要:The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids.
专利号:US-2016108436-A1 优先权日:2014-05-16 标题:Synthesis of olefinic alcohols via enzymatic terminal hydroxylation
专利号:WO-2016210352-A2 优先权日:2015-06-24 标题 :Synthesis of pheromones and other oxy-functionalized products via enzymatic hydroxylation of carboxylic acids
专利号:WO-2015176020-A1 优先权日:2014-05-16 标题 :Synthesis of olefinic alcohols via enzymatic terminal hydroxylation
摘要:Matsumoto, K.; Katsuki, T.; Arends, I. W. C. E., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 79. 摘要:Berkessel, A.; Engler, H.; Leuther, T. M., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 278.