CAS: 10316-79-7; 1-Amino-1-Cyclopentanemethanol

上下游产品

ethyl 1-amin°Cyclopentanecarboxylate 1-azido-1-hydroxymethylcyclopentane 1-amino-1-cyclopentanecarboxylic acid 1-oxaspiro[2.4]heptane-1-cyclopentanmethanol1(6-Chlor-5-nitro-4-pyrimidinyl)amino-1-cyclopentanmethanol -1,1'-dicyclopentanmethanol1,1'-(5-Nitro-4,6-pyrimidindiyl)diamino-1,1'-dicyclopentanmethanol 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 7-Benzyl-2-(1-hydroxymethyl-cyclopentylamino)-1-methyl-8-phenyl-1,7-dihydro-purin-6-one

环亮氨酸置于氯化亚砜,红铝体系中,用 甲苯 用作溶剂,化学反应 2.0H,反应生成1-氨基-1-环戊基甲醇
参考文献:用于生物筛选的fsp 3-富双螺旋基复合文库的设计与合成
标题:用于生物筛选的fsp 3-富双螺旋基复合文库的设计与合成
摘要:探索创新的化学空间是药物发现早期阶段的关键步骤.双螺环骨架存在于天然产物和其他生物学相关的代谢物中,并显示出诱人的特征,例如分子致密性,结构复杂性和三维特征.已经开发了一种简单的合成双螺环化合物库的方法,该方法从容易获得的市售试剂和稳健的化学转化开始.介绍了许多在欧洲铅工厂项目中实施的新型双螺环支架实例.
Doi:10.1021/acscombsci.6B00005

专利信息

专利号:US-9950988-B2
优先权日:2012-12-26
标题:Method for the synthesis of alpha/alpha-prime-alcoxylated glycerol linear carbonic esters
发明人：LEISING FRéDéRIC; MOULOUNGUI ZéPHIRIN
权利人:CHRYSO; INST NAT POLYTECHNIQUE TOULOUSE; INST NAT DE LA RECH AGRONOMIQUE INRA
摘要:A method for the synthesis of α/α′-alcoxylated glycerol linear carbonic esters, wherein the following are brought into contact at a reaction temperature lower than 220° C.: a quantity of at least one precursor selected from the group consisting of α/α′-alcoxylated glycerol cyclo-carbonates; a quantity of at least one catalyst selected from the group consisting of metal oxides, Lewis acids, organometallic catalysts and mineral bases; and a quantity of at least one organic primer. A composition containing at least one novel α/α′-alkoxylated glycerol linear carbonic ester.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2015329468-A1
优先权日:2012-12-26
标题 :Method for the synthesis of alpha/alpha-prime-alcoxylated glycerol linear carbonic esters

专利号:US-6660832-B1
优先权日:1999-08-20
标题:Macrocyclic compounds and preparation methods thereof
发明人：JEFFERSON ELIZABETH; SWAYZE ERIC EDWARD
权利人:ISIS PHARMACEUTICALS INC
摘要:The present invention is directed to macrocyclic compounds of the formula (I)wherein Q, X, R1 and R5 are as defined herein. Compounds of the invention are useful for therapeutic and prophylactic treatment of bacterial infection in mammals. Solid phase synthetic procedures are provided effecting synthesis of the macrocyclic rings attached to a solid support.

专利号:US-5104947-A
优先权日:1989-08-07
标 题:Polyphosphazenes and their synthesis
发明人：SCHACHT ETIENNE; CROMMEN JAN
权利人:ETHYL CORP
摘要:Described are polyphosphazenes which may be represented by the general formula ##STR1## in which R is a hydroxy-substituted or protected hydroxy-substituted saturated aliphatic group, R' is a hydrocarbyl group, R' is a residue of an alpha amino acid, n is from about 50 to about 25,000, and x is a number averaging from 0.05 to 1.00 per repeating unit and y is a number averaging from 0.95 to 0.00 per repeating unit so that per repeating unit the sum of x and y is 1. Removal of the protecting group in the R moiety renders the polymers water soluble. The polymers have a controllable set of properties including degree of hydrolytic stability, permeability, hydrophilicity, and bioacceptability. They may be used in the production of hydrogels for drug release systems, plasma extenders, and biomedical implants.