CAS: 88241-65-0; (E)-3-([1,1'-Biphenyl]-4-yl)Acrylic Acid

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CAS号35888-99-4 3-(4-联苯基)丙酸 | CAS号1459-05-8 1-methyl-3-(4-p... | CAS号28065-98-7 2-phenyl-9H-fluorene | CAS号28952-41-2 1-methyl-4-(4-p... | CAS号78733-60-5 3-BIPHENYL-4-YL... | CAS号61221-46-3 1-(3-chloroprop...

合成工艺路线路线简述

  • 3218-36-8 = 88241-65-0
    反应条件:1.1 Reagents: Titanium Tetrachloride Solvents: Dichloromethane; 20 Min,Rt1.2 Reagents: Triethylamine; 10 Min,Rt; 3 - 4 H,Rt
    标题:Ticl4-Mediated Olefination Of Aldehydes With Acetic Acid And Alkyl Acetates. A Stereoselective Approach To (E)-α,β-Unsaturated Carboxylic Acids And Esters
    作者:Augustine,John Kallikat; Et Al
    参考文献:Tetrahedron Letters 日期:2014 卷标:55(24) 页码:3503-3506]

    141-82-2 + 3218-36-8 = 88241-65-0
    反应条件:1.1 Reagents: Piperidine Solvents: Pyridine; 24 H,80 - 90 °C
    标题:Synthesis,Molecular Modeling,And Biological Evaluation Of Cinnamic Acid Metronidazole Ester Derivatives As Novel Anticancer Agents
    作者:Qian,Yong; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2010 卷标:18(14) 页码:4991-4996]

    = 88241-65-0
    反应条件:1.1 Reagents: Lithium Tert-Butoxide,Bis(Pinacolato)Diborane Catalysts: Cuprous Iodide,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Dimethylacetamide; 24 H,60 °C; 60 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
    标题:Stereoselective Defluorinative Carboxylation Of Gem-Difluoroalkenes With Carbon Dioxide
    作者:Xie,Shi-Liang; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2019 卷标:6(21) 页码:3678-3682]

    76985-08-5 = 88241-65-0 + 170080-13-4
    反应条件:1.1 Catalysts: β-Cyclodextrin,Phenylalanine Ammonia-Lyase Solvents: Water; 40 H,Ph 8.8,30 °C1.2 Solvents: Methanol; 30 °C
    标题:Tailored Mutants Of Phenylalanine Ammonia-Lyase From Petroselinum Crispum For The Synthesis Of Bulky L- And D-Arylalanines
    作者:Filip,Alina; Et Al
    参考文献:Chemcatchem 日期:2018 卷标:10(12) 页码:2627-2633]

    63024-50-0 = 88241-65-0 + 170080-13-4
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Water; 7 H,Reflux2.1 Catalysts: β-Cyclodextrin,Phenylalanine Ammonia-Lyase Solvents: Water; 40 H,Ph 8.8,30 °C2.2 Solvents: Methanol; 30 °C
    标题:Tailored Mutants Of Phenylalanine Ammonia-Lyase From Petroselinum Crispum For The Synthesis Of Bulky L- And D-Arylalanines
    作者:Filip,Alina; Et Al
    参考文献:Chemcatchem 日期:2018 卷标:10(12) 页码:2627-2633]

    2567-29-5 + 1068-90-2 = 88241-65-0 + 170080-13-4
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 30 Min,Rt1.2 Solvents: Dimethylformamide; 0 °C; 3 H,Rt; 4 H,60 °C2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 4 - 6 H,Reflux2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,-10 °C2.3 Solvents: Toluene; 16 - 24 H,Reflux3.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Water; 7 H,Reflux4.1 Catalysts: β-Cyclodextrin,Phenylalanine Ammonia-Lyase Solvents: Water; 40 H,Ph 8.8,30 °C4.2 Solvents: Methanol; 30 °C
    标题:Tailored Mutants Of Phenylalanine Ammonia-Lyase From Petroselinum Crispum For The Synthesis Of Bulky L- And D-Arylalanines
    作者:Filip,Alina; Et Al
    参考文献:Chemcatchem 日期:2018 卷标:10(12) 页码:2627-2633]

    141-82-2 + 3218-36-8 = 88241-65-0
    反应条件:1.1 Catalysts: Piperidine Solvents: Pyridine; 2 H,Reflux
    标题:Rational Modifications On A Benzylidene-Acrylohydrazide Antiviral Scaffold,Synthesis And Evaluation Of Bioactivity Against Chikungunya Virus
    作者:Giancotti,Gilda; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2018 卷标:149 页码:56-68]

    141-82-2 + 3218-36-8 = 88241-65-0
    反应条件:1.1 Catalysts: Piperidine Solvents: Pyridine; 24 H,80 - 90 °C
    标题:Synthesis,Molecular Modeling And Biological Evaluation Of β-Ketoacyl-Acyl Carrier Protein Synthase Iii (Fabh) As Novel Antibacterial Agents
    作者:Zhang,Hong-Jia; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(15) 页码:4513-4519]

    113538-22-0 = 88241-65-0
    反应条件:1.1 Reagents: Hydrogen Peroxide,Sodium Chlorite
    标题:Traceless Sulfone Linker Cleavage Triggered By Ozonolysis: Solid-Phase Synthesis Of Diverse α-β-Unsaturated Carbonyl Compounds
    作者:Chang,Yi-Fan; Et Al
    参考文献:Tetrahedron Letters 日期:2008 卷标:49(3) 页码:543-547]

    30166-77-9 = 88241-65-0
    反应条件:1.1 Reagents: Tetrabutylammonium Tetrafluoroborate Solvents: Dimethylformamide; 8 H,1 Atm,35 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Stereoselective Electrochemical Carboxylation Of α,β-Unsaturated Sulfones
    作者:Yang,Zi-Xin; Et Al
    参考文献:Chinese Chemical Letters 日期:2023 卷标:34(6)]

    867-13-0 + 3218-36-8 = 88241-65-0
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0 °C; 30 Min,0 °C1.2 1 - 3 H,Rt1.3 Reagents: Acetic Acid,Water; Rt1.4 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 6 - 24 H,Rt1.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 2,Rt
    标题:Visible-Light Promoted Oxidative Cyclization Of Cinnamic Acid Derivatives Using Xanthone As The Photocatalyst
    作者:Zhao,Bin; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2021 卷标:19(3) 页码:568-573]

    352530-23-5 = 88241-65-0
    反应条件:1.1 Reagents: Potassium Methoxide Catalysts: Cuprous Chloride Solvents: Dimethylacetamide; 24 H,1 Atm,70 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Carboxylation Of Alkenyl Boronic Acids And Alkenyl Boronic Acid Pinacol Esters With Co2 Catalyzed By Cuprous Halide
    作者:Hong,Junting; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2020 卷标:2020(19) 页码:2813-2818]

    2350-89-2 = 88241-65-0
    反应条件:1.1 Reagents: Dimethyl Sulfoxide Catalysts: Cobalt Iodide (Coi2),Eosin; 15 H,50 °C
    标题:Carboxylation Of Styrenes With Cbr4 And Dmso Via Cooperative Photoredox And Cobalt Catalysis
    作者:Song,Cai-Xia; Et Al
    参考文献:Rsc Advances 日期:2017 卷标:7(19) 页码:11233-11243]

    98-80-6 + 589-15-1 + 22037-73-6 = 88241-65-0
    反应条件:1.1 Solvents: Dimethylformamide,Tetrahydrofuran; 60 °C1.2 Reagents: Potassium Carbonate,Sodium Benzenesulfinate (Resin-Bound) Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane,Water; 90 °C1.3 Reagents: Dimethyl Sulfoxide,Butyllithium; 5 Min,Rt1.4 Solvents: Tetrahydrofuran; 30 Min,Rt1.5 Solvents: Tetrahydrofuran; Rt1.6 Reagents: Ozone Solvents: Dichloromethane; 5 Min,0 °C1.7 Reagents: Sodium Methoxide Solvents: Methanol,Dichloromethane; 3 H,Rt2.1 Reagents: Hydrogen Peroxide,Sodium Chlorite
    标题:Traceless Sulfone Linker Cleavage Triggered By Ozonolysis: Solid-Phase Synthesis Of Diverse α-β-Unsaturated Carbonyl Compounds
    作者:Chang,Yi-Fan; Et Al
    参考文献:Tetrahedron Letters 日期:2008 卷标:49(3) 页码:543-547]

    98-80-6 + 589-15-1 = 88241-65-0
    反应条件:1.1 Solvents: Dimethylformamide,Tetrahydrofuran; 60 °C1.2 Reagents: Potassium Carbonate,Sodium Benzenesulfinate (Resin-Bound) Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: 1,2-Dimethoxyethane,Water; 90 °C1.3 Reagents: Dimethyl Sulfoxide,Butyllithium; 5 Min,Rt1.4 Solvents: Tetrahydrofuran; 30 Min,Rt1.5 Solvents: Tetrahydrofuran; Rt1.6 Reagents: Ozone Solvents: Dichloromethane; 5 Min,0 °C1.7 Reagents: Sodium Methoxide Solvents: Methanol,Dichloromethane; 3 H,Rt2.1 Reagents: Hydrogen Peroxide,Sodium Chlorite
    标题:Traceless Sulfone Linker Cleavage Triggered By Ozonolysis: Solid-Phase Synthesis Of Diverse α-β-Unsaturated Carbonyl Compounds
    作者:Chang,Yi-Fan; Et Al
    参考文献:Tetrahedron Letters 日期:2008 卷标:49(3) 页码:543-547]

    1779-49-3 + 3218-36-8 = 88241-65-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran; 10 H,75 °C2.1 Reagents: Dimethyl Sulfoxide Catalysts: Cobalt Iodide (Coi2),Eosin; 15 H,50 °C
    标题:Carboxylation Of Styrenes With Cbr4 And Dmso Via Cooperative Photoredox And Cobalt Catalysis
    作者:Song,Cai-Xia; Et Al
    参考文献:Rsc Advances 日期:2017 卷标:7(19) 页码:11233-11243]

    873-55-2 + 2350-89-2 = 88241-65-0
    反应条件:1.1 Reagents: Sodium Acetate,Iodine Solvents: Acetonitrile; 3 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water1.3 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized2.1 Reagents: Tetrabutylammonium Tetrafluoroborate Solvents: Dimethylformamide; 8 H,1 Atm,35 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Stereoselective Electrochemical Carboxylation Of α,β-Unsaturated Sulfones
    作者:Yang,Zi-Xin; Et Al
    参考文献:Chinese Chemical Letters 日期:2023 卷标:34(6)]

    63024-21-5 = 88241-65-0 + 170080-13-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 4 - 6 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,-10 °C1.3 Solvents: Toluene; 16 - 24 H,Reflux2.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Water; 7 H,Reflux3.1 Catalysts: β-Cyclodextrin,Phenylalanine Ammonia-Lyase Solvents: Water; 40 H,Ph 8.8,30 °C3.2 Solvents: Methanol; 30 °C
    标题:Tailored Mutants Of Phenylalanine Ammonia-Lyase From Petroselinum Crispum For The Synthesis Of Bulky L- And D-Arylalanines
    作者:Filip,Alina; Et Al
    参考文献:Chemcatchem 日期:2018 卷标:10(12) 页码:2627-2633]

    3597-91-9 = 88241-65-0 + 170080-13-4
    反应条件:1.1 Reagents: N-Bromosuccinimide,Triphenylphosphine Solvents: Dichloromethane; 30 Min,Rt2.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 30 Min,Rt2.2 Solvents: Dimethylformamide; 0 °C; 3 H,Rt; 4 H,60 °C3.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 4 - 6 H,Reflux3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,-10 °C3.3 Solvents: Toluene; 16 - 24 H,Reflux4.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Water; 7 H,Reflux5.1 Catalysts: β-Cyclodextrin,Phenylalanine Ammonia-Lyase Solvents: Water; 40 H,Ph 8.8,30 °C5.2 Solvents: Methanol; 30 °C
    标题:Tailored Mutants Of Phenylalanine Ammonia-Lyase From Petroselinum Crispum For The Synthesis Of Bulky L- And D-Arylalanines
    作者:Filip,Alina; Et Al
    参考文献:Chemcatchem 日期:2018 卷标:10(12) 页码:2627-2633]

    3218-36-8 = 88241-65-0 + 170080-13-4
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol; Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 3,Rt2.1 Reagents: N-Bromosuccinimide,Triphenylphosphine Solvents: Dichloromethane; 30 Min,Rt3.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 30 Min,Rt3.2 Solvents: Dimethylformamide; 0 °C; 3 H,Rt; 4 H,60 °C4.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 4 - 6 H,Reflux4.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,-10 °C4.3 Solvents: Toluene; 16 - 24 H,Reflux5.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Water; 7 H,Reflux6.1 Catalysts: β-Cyclodextrin,Phenylalanine Ammonia-Lyase Solvents: Water; 40 H,Ph 8.8,30 °C6.2 Solvents: Methanol; 30 °C
    标题:Tailored Mutants Of Phenylalanine Ammonia-Lyase From Petroselinum Crispum For The Synthesis Of Bulky L- And D-Arylalanines
    作者:Filip,Alina; Et Al
    参考文献:Chemcatchem 日期:2018 卷标:10(12) 页码:2627-2633

海关参考信息

专利信息


专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-3975429-A
优先权日:1973-11-05
标题:Cyclopropanemethyl esters of cinnamic acid and derivatives thereof
发明人：HENRICK CLIVE A; STAAL GERARDUS B
权利人:ZOECON CORP
摘要:Organic esters and thioesters characterized by the presence of a cyclopropane moiety, synthesis thereof, and compositions thereof for the control of mites and ticks.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.

专利号:CN-114230519-B
优先权日:2021-12-06
标题:A class of pleuromutilin cinnamate compounds with anti-drug-resistant bacteria activity and synthesis method and application thereof

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合成参考文献


参考文献:10.1007/978-3-662-26312-9_1
参考文献:10.1055/s-0034-1378718
摘要:Du Y, Zhao K, Liu L, Zhang-Negrerie D. Hypervalent Iodine Mediated C–C Double Bond Activation: A Cascade Access to α-Keto Diacetates from Readily Available Cinnamic Acids. Synthesis. 2015 Jun 24;47(19):2924–30. doi: 10.1055/s-0034-1378718.
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