CAS: 85148-26-1; 3-Chloro-5-(Trifluoromethyl)Pyridine

相似化合物

69045-84-7 3796-23-4 72537-17-8

上下游产品

CAS号69045-84-7 2,3-二氯-5-三氟甲基吡啶 | CAS号72537-17-8 3-氯-2-氟-5-(三氟甲基)吡啶 | CAS号131747-59-6 (5-(三氟甲基)吡啶-3-基)甲醇 | CAS号131747-40-5 5-三氟甲基烟酸 | CAS号112110-07-3 3-氨基-2-三氟甲基吡啶 | CAS号186593-14-6 3-羟基-5-(三氟甲基)吡啶 | CAS号131747-67-6 5-(三氟甲基)吡啶-3-甲醛

2,3-二氯-5-三氟甲基吡啶置于palladium 10% On Activated Carbon,甲酸铵体系中,用 甲醇,水 作为反应溶剂,化学反应 2.0H,反应生成 3-氯-5-三氟甲基吡啶
参考文献:N-苯基-N '-[4-(5 H-吡咯并[3,2-D]嘧啶-4-基氧基)苯基]脲作为vegfr和fgfr激酶的新型抑制剂
标题:N-苯基-N '-[4-(5 H-吡咯并[3,2-D]嘧啶-4-基氧基)苯基]脲作为vegfr和fgfr激酶的新型抑制剂
摘要:我们最近报道了吡咯并[3,2-D]嘧啶衍生物1A和1B作为血管内皮生长因子受体(vegfr),血小板衍生生长因子受体(pdgfr)和tie-2激酶的有效三重抑制剂的发现.为了鉴定对成纤维细胞生长因子受体(fgfr)激酶具有强抑制活性的化合物,使用vegfr2和1B的共晶体结构分析进行了进一步修饰.在合成的化合物中,在末端苯环上具有哌嗪部分的尿素衍生物11L显示出对fgfr1激酶和vegfr2激酶的强抑制活性.11L的绑定模型 与vegfr2复合表明哌嗪部分与ile1025和his1026形成额外的相互作用.
DOI:10.1016/j.Bmc.2010.08.042

专利信息

专利号:WO-2011092618-A1
优先权日:2010-01-28
标题 :Method for the preparation of fluazinam
发明人：PASTORIO ANDREA; MORA CLAUDIA
权利人:FINCHIMICA SRL; PASTORIO ANDREA; MORA CLAUDIA
摘要:A method for the synthesis of 3-chloro, N- (3-chloro-5- trifluoromethyl-2-pyridyl), α, α, α-trif luoro, 2,6-dinitro- p-toluidine (Fluazinam) comprises an amination reaction of a pyridine, to obtain 2-amino, 3-chloro, 5- trif luoromethylpyridine, the addition of a strong base to the 2-amino, 3-chloro, 5-trif luoromethylpyridine, and a formation reaction of Fluazinam by coupling of the 2- amino-3-chloro-5-trif luoromethylpyridine with the 2,4- dichloro, 3,5-dinitro, benzotrif luoride. The amination reaction is conducted with anhydrous ammonia in an organic solvent. Furthermore, the coupling reaction as above takes place directly in the solution of Pyridine 2 coming from the amination step.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:CN-101781245-A
优先权日:2009-06-26
标题 :A new method for the synthesis of substituted pyridine-3-carboxylic acids and analogues

专利号:WO-2024022910-A1
优先权日:2022-07-26
标题 :1-[1-[2-(pyrimidin-4-yl)-1,2,4-triazol-3-yl]ethyl]-3-[2,4-dichloro-5-phenyl]urea derivatives and similar compounds as pesticides
发明人：WEISS MATTHIAS; JEANGUENAT ANDRE; KILARU JAGADEESH PRATHAP; MUEHLEBACH MICHEL; SCARBOROUGH CHRISTOPHER CHARLES; STOLLER ANDRé; SUESSE LARS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to compounds of formula (I) wherein: X is O or S; Q is Q a or Q b as pesticides and insecticides. Preferred compounds are e.g. 1-[1-[2-(pyrimidin-4-yl)-1,2,4-triazol-3-yl]ethyl]-3-[2,4-dichloro-5-phenyl]urea derivatives and similar compounds. An exemplary compound is e.g. 1-[(1S)-1-[2-(6-cyanopyrimidin-4-yl) -1,2,4-triazol-3-yllethyll-3-[2,4-dichloro-5-(trifluoromethyl)phenyllurea (example E1; compound P1). The present invention discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof.

专利号:US-8318928-B2
优先权日:2008-12-15
标题 :Fused imidazole carboxamides as TRPV3 modulators
发明人：CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
权利人:CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI; GLENMARK PHARMACEUTICALS SA
摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

专利号:CN-119219553-A
优先权日:2024-09-25
标 题 :Synthesis method of 3-chloro-2-aminoethyl-5-trifluoromethyl pyridine