CAS: 74289-57-9; Bis(3,5-Dimethylphenyl)Chlorophosphine

上下游产品

bis(3,5-dimethylphenyl)phosphine oxide [bis-(3,5-dimethylphenyl)](diethylamino)phosphine diethylphosphoramidous dichloride 3,5-dimethyphenylmagnesium bromidemethyl 2,6-di-O-benzoyl-3,4-bis-O-(bis(3,5-dimethylphenyl)phosphino)-α-D-glucopyranoside

📜3,5-二甲基溴苯置于magnesium,1,2-二溴乙烷,二乙基二氯磷,盐酸体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,反应生成 氯二(3,5-二甲基苯基)膦
参考文献:羧酸衍生物的钯催化烯丙基烷基化:N-酰基恶唑啉酮作为酯烯醇化物等价物
标题:羧酸衍生物的钯催化烯丙基烷基化:N-酰基恶唑啉酮作为酯烯醇化物等价物
摘要:Triple A:报道了在羧酸氧化态下酯烯醇化物等价物的一般不对称烯丙基烷基化.n-酰基苯并恶唑啉酮衍生的烯醇碳酸酯被合成并用于钯催化的烷基化反应.酰亚胺产物很容易转化为一系列羧酸衍生物,而不会损失对映纯度.
DOI:10.1002/anie.201105801

专利信息

专利号:US-9518014-B2
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process
发明人：DING KUILING; WANG XIAOMING; WANG ZHENG
权利人:SHANGHAI INST ORGANIC CHEMISTRY CAS
摘要:A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly.

专利号:US-9062085-B2
优先权日:2010-09-10
标 题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
发明人：ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO
权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC
摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))

专利号:US-2015166479-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:EP-2876102-A1
优先权日:2012-07-20
标 题 :Process for synthesis of ezetimibe and intermediates used in said process

专利号:EP-2876102-B1
优先权日:2012-07-20
标 题:Process for synthesis of ezetimibe and intermediates used in said process