CAS: 7423-92-9; (S)-2-Amino-3-(2-Hydroxyphenyl)Propanoic Acid

上下游产品

L-phenylalanine 2-hydroxy-phenylalanine o-Coumaric acid Hippuric Acid L-Aspartic acid methyl 2-amino-3-(2-hydroxyphenyl)propanoate (Hydr°Chloride) 2-hydroxy-3,5-diiodo-phenylalanine N-chloroacetyl-2-hydroxy-phenylalanineN-chloroacetyl-2-hydroxy-phenylalanine

Dl-O-络氨酸 反应生成 L-2-羟基苯丙氨酸
参考文献:铜(II)-D-邻酪氨酸络合物的分光光度研究.铜(II)和铁(iii)转铁蛋白中330 Nm二向色带的分配
标题:铜(II)-D-邻酪氨酸络合物的分光光度研究.铜(II)和铁(iii)转铁蛋白中330 Nm二向色带的分配
摘要:已经通过联萘基磷酸分离了外消旋邻酪氨酸的两种对映异构体.铜(II)与d-O-酪氨酸相互作用形成两个配合物.第一种是在ph值为6时获得的,它具有通过氨基氮和羧酸氧与金属配位的圆二色性(cd)光谱图.第二种复合物在ph 8处开始形成,并在ph 10.5处完全定义.它的cd光谱在低于400 Nm的区域内,与铁(iii)和铜(II)转铁蛋白非常相似,并且在大约200 Nm处显示两个明确定义的谱带.400和330 Nm.到目前为止,只有高频峰的起源是由酚盐-氧-金属至电荷的转移跃迁引起的,而低频峰的起源仍不确定.激发进入400和330 Nm的两个吸收的包络线后的共振拉曼测量清楚地表明了这两个谱带的共同起源,即:酚盐氧-> Cu Ii电荷转移跃迁.
DOI:10.1039/dt9810002544

专利信息

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2013131343-A1
优先权日:2009-12-07
标 题:Microwave-assisted synthesis of n-heterocyclic carbene transition metal complexes
发明人：NAVARRO OSCAR; WINKELMANN OLE H
权利人:NAVARRO OSCAR; WINKELMANN OLE H; UNIV HAWAII
摘要:Microwave heating is used to synthesize NHC-transition metal complexes. Reaction times for the formation of NHC-transition metal complexes is greatly reduced. The speed of the reactions allows for otherwise problematic air handling of reagents. Apparatus for carrying out the reactions is less complex than conventional apparatus and requires less energy to achieve the desired temperatures. Methods utilize salts of NHC's which overcomes the oftentimes difficult preparation of free carbenes for formation of the corresponding transition metal complexes.

专利号:US-5633346-A
优先权日:1992-06-19
标 题:Process for systhesizing cyclic peptides
发明人：KUROME TORU; TAKESAKO KAZUTOH; KATO IKUNOSHIN; INAMI KAORU; SHIBA TETSUO
权利人:TAKARA SHUZO CO
摘要:A process is provided for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. The cyclic peptide is represented by the following formula (I): (I) wherein X1, X2, X4 and X7 are independently N-methyl- alpha -amino acid or alpha -hydroxy acid, provided that at least one of X1, X2, X4 and X7 is an alpha -hydroxy acid; X3, X6 and X8 are independently alpha -amino acid; X5 is a cyclic amino acid; X9 is an N-methyl- alpha -amino acid or alpha -hydroxy acid substituted by a hydroxy group; and the dotted lines represent intramolecular hydrogen bonds. The process includes cyclizing a corresponding linear peptide between X5 and X6 via a peptide bond.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2011071881-A2
优先权日:2009-12-07
标 题:Microwave-assisted synthesis of n-heterocyclic carbene transition metal complexes