CAS: 742-20-1; 6-Chloro-3-(Cyclopentylmethyl)-3,4-Dihydro-2H-Benzo[e][1,2,4]Thiadiazine-7-Sulfonamide 1,1-Dioxide

该化合物是硫酸二甲酸酯,主要用于高血压和水肿管理,与凝固性心脏衰竭,肾功能失调或肝硬化有关.其行动机制包括抑制溶液管中的氯化钠交接器,促进氮化和二尿化.关键优势包括其可预测的药效动力学,中等能效和与强化抗血压效应综合疗法的兼容性.在适当剂量施用时,Cyclopenthiazide还展示了一种有利的安全性特征,对电解性失衡进行了监测.其长半衰期允许每天一次施用,改善病人的耐性.该化合物研究周密,在减少血压和临床环境中的液体保留方面已经取得了既定效力.

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CAS号121-30-2 4-氨基-6-氯-1,3-苯二磺酰胺 | CAS号5623-81-4 环戊基乙醛

合成工艺路线路线简述

    📜6-Chlor-7-Sulfamoyl-3-Cyclopentylmethyl-1,2,4-Benzothiadiazin-1,1-Dioxid置于sodium Tetrahydroborate,三氯化铝体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 环戊噻嗪
    参考文献:Diuretics. V. 3,4-Dihydro-1,2,4-Benzothiadiazine 1,1-Dioxides
    标题:Diuretics. V. 3,4-Dihydro-1,2,4-Benzothiadiazine 1,1-Dioxides
    摘要:
    DOI:10.1021/jo01066A046

    海关参考信息

    专利信息


    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-10005720-B2
    优先权日:2013-04-05
    标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
    发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
    权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
    摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

    专利号:US-2018370905-A1
    优先权日:2013-04-05
    标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

    专利号:KR-101513003-B1
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy compositions and applications

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:AU-2007308022-A2
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Krum H, Jackson B, Conway EL, Howes LG, Johnston CI, Louis WJ. Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. J Cardiovasc Pharmacol. 1992 Sep;20(3):451-7.
    7: Harding JJ, van Heyningen R. Drugs, including alcohol, that act as risk factors for cataract, and possible protection against cataract by aspirin-like analgesics and cyclopenthiazide. Br J Ophthalmol. 1988 Nov;72(11):809-14.
    8: McVeigh G, Galloway D, Johnston D. The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide. BMJ. 1988 Jul 9;297(6641):95-8.

    合成参考文献


    参考文献:10.1186/1471-2407-11-304
    摘要:Sadanandam A, Futakuchi M, Lyssiotis CA, Gibb WJ, Singh RK. A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling. BMC Cancer. 2011 Jul 20;11():304.
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