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3-(3-氟苯基)丙酸置于ppa体系中,化学反应生成 5-氟-1-茚酮
参考文献:化学治疗硝基杂环,Iii.取代的1-茚满酮和1-四氢萘酮的硝基糠叉基,亚硝基亚乙基和硝基吡咯基亚甲基化合物的制备
标题:化学治疗硝基杂环,Iii.取代的1-茚满酮和1-四氢萘酮的硝基糠叉基,亚硝基亚乙基和硝基吡咯基亚甲基化合物的制备
摘要:1-茚满酮和1-四氢萘酮与5-硝基糠醛,5-硝基糠醛二乙酸酯,5-硝基噻吩-2-醛,5-硝基噻吩-2-醛二乙酸酯,5-硝基吡咯有衍生物将-2-醛或n-甲基-5-硝基-吡咯-2-醛缩合(8-66,表1).在由h 3 Po 4引起缩合的情况下,乙酰氨基同时水解,在乙酸酐发生缩合的情况下,同时进行oh基的乙酰化反应(78-83,表2).).描述了在苯核上取代的新的1-茚满酮和1-四氢萘酮衍生物.
DOI:10.1002/jlac.19707360112

专利信息

专利号:WO-2023122754-A1
优先权日:2021-12-23
标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

专利号:US-6316437-B1
优先权日:1999-09-30
标题:Spirohydantoin compounds and uses thereof
发明人：HOFFMAN JACOB M
权利人:MERCK & CO INC
摘要:Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are typically selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia can be achieved.

专利号:US-2023002426-A1
优先权日:2019-11-15
标题 :Chiral synthesis of a tertiary alcohol

专利号:US-5504104-A
优先权日:1993-11-19
标 题:Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
发明人：ELLSWORTH EDMUND L; TAIT BRADLEY D
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel substituted tricyclic pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The tricyclic pyrone derivatives are useful in the development of therapies for the treatment of vital infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized tricyclic pyrones and of related structures.

专利号:WO-2021097139-A1
优先权日:2019-11-15
标 题 :Chiral synthesis of a tertiary alcohol

专利号:CN-119798018-A
优先权日:2024-11-29
标题:Synthesis method of benzo cyclic ketone compound alpha-site dichloro substitution