CAS: 698-25-9; 6-Chloro-1H-Indazole

4-氯-2-羟基苯甲醛置于hydrazine Hydro-Chloride体系中,用 乙醇 作为反应溶剂,化学反应 3.0H,反应生成 6-氯-1H-吲唑
参考文献:Synthesis,Antifungal Activity And Qsar Of Novel Pyrazole Amides As Succinate Dehydrogenase Inhibitors
标题:Synthesis,Antifungal Activity And Qsar Of Novel Pyrazole Amides As Succinate Dehydrogenase Inhibitors
摘要:We Design And Synthesize A Series Of Novel Pyrazole Amides Based On The Commercialized Fungicides And Our Previous Work. The Antifungal Activity Was Tested In Vitro By Mycelial Growth Inhibition Assay. The Results Show That All The Compounds Are Of Antifungal Activities Against The Tested Fungi At Different Levels. Among Them,N-(2-(7-Bromo-5-Chloro-1H-Indazol-1-yl)Phenyl)-3-(Difluoromethyl)-1-Methyl-1H-Pyrazole-4-Carboxamide (Vk) Exhibited Higher Antifungal Activity Than Boscalid Against Two Fungi. Molecular Docking Study Revealed That The Carbonyl Oxygen Atom Of Vk Forms Two Hydrogen Bonds Toward The Hydroxyl Hydrogens Of Tyr58 And Trp173.
DOI:10.3987/com-17-13826

专利信息

专利号:JP-2010222357-A
优先权日:2002-03-11
标题 :Intermediate compounds for the synthesis of aminoindazole derivatives

专利号:JP-5315287-B2
优先权日:2002-03-11
标 题 :Intermediate compounds for the synthesis of aminoindazole derivatives