CAS: 55179-31-2; Bitertanol

该化合物是一种属于三甲醇等级的系统性杀真菌剂,主要用于农业,以控制作物中各种真菌疾病,它的作用是抑制作为真菌细胞膜基本成分的egosterol的生物合成,从而干扰细胞生长和生殖.Bitertanol的特点是其中,高的抗病原(如微粒粉和生锈)的功效,使其在植物健康管理中具有价值.该物质通常作为一种花生喷雾施用,以其相对较低的对哺乳动物的毒性而著称,这有助于其在农业应用中取得有利的安全特征.此外,Bitertanol具有良好的环境稳定性,尽管其持久性取决于土壤和气候条件.其化学结构具有三甲醇的特征,这是该类杀真菌剂中常见的,有助于其作用模式.与任何农药一样,妥善处理和遵守安全准则对于最大限度地减少非目标生物和环境的潜在风险至关重要.

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CAS号555-31-7 异丙醇铝 | CAS号43121-37-5 1-([1,1'-biphen...

合成工艺路线路线简述

  • 合成目标产物 Bitertanol 主要起始原料 Aluminium Isopropoxide And 1-([1,1'-Biphenyl]-4-Yloxy)-3,3-Dimethyl-1-(1H-1,2,4-Triazol-1-yl)Butan-2-One
  • (文献来源)合成步骤主要原料 Aluminium Isopropoxide 和 1-([1,1'-Biphenyl]-4-Yloxy)-3,3-Dimethyl-1-(1H-1,2,4-Triazol-1-yl)Butan-2-One
📜1-([1,1'-联苯]-4-基氧基)-3,3-二甲基-1-(1H-1,2,4-三唑-1-基)丁烷-2-酮置于sodium Tetrahydroborate体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.0H,反应生成 联苯三唑醇
参考文献:Reuther,Wolfgang; Ruland,Alfred; Baus,Ulf,Liebigs Annalen Der Chemie,1988,P. 235-240
标题:Reuther,Wolfgang; Ruland,Alfred; Baus,Ulf,Liebigs Annalen Der Chemie,1988,P. 235-240

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专利信息


专利号:US-4751312-A
优先权日:1984-07-20
标 题:Process and intermediates for the synthesis of diastereomeric compounds
发明人:GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF
权利人:BAYER AG
摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

专利号:US-9968097-B2
优先权日:2012-05-30
标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
权利人:BAYER CROPSCIENCE AG
摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

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✅ COA系统入驻 | 共享模式

主要参考文献


1: Bourgin M, Violleau F, Debrauwer L, Albet J. Kinetic aspects and identification of by-products during the ozonation of bitertanol in agricultural wastewaters. Chemosphere. 2013 Jan;90(4):1387-95. doi: 10.1016/j.chemosphere.2012.08.014. Epub 2012 Sep 20. Epub 2006 Aug 8. doi: 10.1016/j.taap.2015.02.004. Epub 2015 Feb 12. doi: 10.1016/j.envpol.2016.11.051. Epub 2016 Dec 21. doi: 10.1016/j.taap.2013.06.028. Epub 2013 Jul 16. doi: 10.1002/chir.22385. Epub 2014 Oct 20. Japanese. doi: 10.1016/j.ntt.2014.04.068. Epub 2014 May 9. Review. doi: 10.1016/j.taap.2013.07.028. Epub 2013 Aug 14. doi: 10.3390/ijerph10062271.
16: Gilbert-López B, García-Reyes JF, Molina-Díaz A. Determination of fungicide residues in baby food by liquid chromatography-ion trap tandem mass spectrometry. Food Chem. 2012 Nov 15;135(2):780-6. doi: 10.1016/j.foodchem.2012.04.059. Epub 2012 May 2. doi: 10.1016/j.aca.2012.06.001. Epub 2012 Jun 12. doi: 10.1002/jssc.201100889.

合成参考文献


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摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1016/j.reprotox.2006.04.008
摘要:Menegola E, Broccia ML, Di Renzo F, Giavini E. Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects. Reprod Toxicol. 2006 Aug;22(2):186–95. doi: 10.1016/j.reprotox.2006.04.008.
参考文献:10.1007/s10661-008-0249-y
摘要:Kozmutza C, Picó Y. To address accuracy and precision using methods from analytical chemistry and computational physics. Environmental Monitoring and Assessment. 2008 Mar 28;151(1-4):59–75. doi: 10.1007/s10661-008-0249-y.
参考文献:10.1007/s00253-018-9037-y
摘要:Zhou Y, Avery PB, Carrillo D, Duncan RH, Lukowsky A, Cave RD, Keyhani NO. Identification of the Achilles heels of the laurel wilt pathogen and its beetle vector. Applied Microbiology and Biotechnology. 2018 May 02;102(13):5673–84. doi: 10.1007/s00253-018-9037-y.
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