CAS: 5464-12-0; 1-(2-Hydroxyethyl)-4-Methylpiperazine

相似化合物

77279-24-4 14000-67-0 54699-92-2

上下游产品

CAS号109-01-3 N-甲基哌嗪 | CAS号540-51-2 2-溴乙醇 | CAS号103-76-4 N-羟乙基哌嗪 | CAS号50-00-0 甲醛 | CAS号107-07-3 2-氯乙醇 | CAS号107-04-0 1-溴-2-氯乙烷 | CAS号28920-67-4 2-(4-甲基哌嗪-1-基)乙酸乙酯 | CAS号75-21-8 环氧乙烷 | CAS号110-85-0 哌嗪 | CAS号110530-52-4 2-(4-methylpipe... | CAS号3563-46-0 2-(4-methylpipe... | CAS号897017-01-5 1-[2-(4-bromo-3... | CAS号646071-39-8 3-methoxy-4-[2-... | CAS号38948-28-6 4-[2-(4-甲基哌嗪-1-... | CAS号63885-81-4 10H-Pyrido[3,2-...

📜N-甲基哌嗪置于sodium Tetrahydroborate,三乙胺体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 18.0H,反应生成 1-(2-羟乙基)-4-甲基哌嗪
参考文献:作为胃泌素释放肽受体拮抗剂的芳香族氨基酸衍生物的设计,合成和止痒活性评估.
标题:作为胃泌素释放肽受体拮抗剂的芳香族氨基酸衍生物的设计,合成和止痒活性评估.
摘要:设计并合成了八种芳香族氨基酸衍生物(9A-9H)作为胃泌素释放肽受体(grpr)拮抗剂.在设计中,以1U19蛋白为模板,通过blast搜索来预测grpr的三级结构.将八种目标化合物停靠在结合袋中,以研究其可能的结合相互作用.通过鞘内注射使用昆明小鼠作为实验动物并用磷酸氯喹作为建模介质来测试它们的抗痒活性.化合物9E和9F显着抑制了刮擦行为.这些化合物的止痒活性按以下顺序降低:计算机辅助药物设计(cadd)预测的9E> 9F = 9D> 9B> 9G> 9A> 9H> 9C和9E> 9F> 9B> 9H> 9G> 9D> 9A> 通过初步测试评估9C.它们基本符合cadd预先测试的活动顺序.结果表明,预测的grpr三级结构可用于止痒药的设计.
DOI:10.2174/157340612802084342

专利信息

专利号:US-3992456-A
优先权日:1969-04-16
标题:Synthesis of alkadienols
发明人：ATKINS KENNETH EARL; MANYIK ROBERT MICHAEL; O'CONNOR GEORGE LAWRENCE
权利人:UNION CARBIDE CORP
摘要:Alkadienols are prepared by reacting a conjugated diolefin, such as butadiene, with water in the presence of palladium or platinum catalyst and in the presence of solvents. The addition of carbon dioxide to the reaction mixture greatly increases the yield of alkadienols. The products can be hydrogenated to saturated alcohols, useful for making plasticizers.

专利号:US-6274735-B1
优先权日:1998-08-10
标 题 :Process and intermediates for preparation of substituted piperidines
发明人：LOHRI BRUNO; SCHMID RUDOLF; VIEIRA ERIC
权利人:HOFFMANN LA ROCHE
摘要:The present invention concerns intermediates useful in and a process for the preparation of a compound of formula 1 or a salt thereof n comprising n a) hydroboration of a compound of formula 2 n A, R 1 and R 2 are as herein defined. These compounds are useful in the synthesis of renin inhibitors.

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-2019013790-A1
优先权日:2017-07-12
标题:ANTIMICROBIAL COMPOUNDS AND USES THEREOF
发明人：REDDY HARIPRASADA; SEBAHAR PAUL; LOOPER RYAN
权利人:CURZA GLOBAL LLC; THE UNIV OF UTAH RESEARCH FOUNDATION
摘要:The invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof. The compounds of formula I are antimicrobial agents which inhibit, for example, Mycobacterium tuberculosis (Mtb) H37Ra. The compounds of formula I also have anti-tuberculous activity, exhibiting limited cytotoxicity, and inhibiting protein synthesis. The invention also relates to methods of making compounds of Formula I, as well as methods of using the compounds of Formula I for the treatment of bacterial infections, particularly tuberculosis.

专利号:US-9481660-B2
优先权日:2006-10-02
标题 :Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use
发明人：HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN
权利人:HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.

专利号:US-8178527-B2
优先权日:2006-10-02
标 题 :Tetra-substituted NDGA derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use
发明人：CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN
权利人:CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; HELLER JONATHAN DANIEL; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue O groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.