CAS: 53298-33-2; (R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(Benzylthio)Propanoic Acid

该化合物是一种受保护的氨酸, 常见于peptide合成中, 常见于一种受保护的氨基酸, 其特点是氟辛基-辛基碳基(Fmoc) 组, 它作为氨基功能的保护群体, 允许在peptide组装过程中有选择性的反应. 苯基(Bzl) 侧链在cysteine 残留物上的存在提供了额外的呆滞, 能够影响peptide 的折叠和稳定性. 这种化合物在外表上一般是白色到白色,在二甲基甲基基胺和二甲基硫基氧化亚基氧化亚基(DMSOFSO) 等有机溶剂中溶解, 而在基本条件下可以去除氟基酸化合物, 其独特的结构可以将cysteineesteine 和硫化物的化学积化物中形成一个至关重要的实地.

结构式图片

相似化合物

3054-01-1 5068-28-0 102830-49-9

上下游产品

CAS号3054-01-1 S-苄基-L-半胱氨酸 | CAS号88744-04-1 9-芴基甲基五氟苯基碳酸酯 | CAS号86060-95-9 N-[(9H-芴-9-基甲氧基... | CAS号103321-55-7 fm°C-cys(bzl)-cl

合成工艺路线路线简述

    📜9-芴甲基-N-琥珀酰亚胺基碳酸酯置于盐酸,Sodium Carbonate,N,N-二异丙基乙胺,锌体系中,用 二氯甲烷,水,乙酸乙酯,丙酮 作为反应溶剂,化学反应 1.0H,反应生成 N-芴甲氧羰基-S-苄基-L-半胱氨酸
    参考文献:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264
    标题:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264

    海关参考信息

    专利信息


    专利号:US-12251674-B2
    优先权日:2012-11-14
    标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis
    发明人:RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA
    权利人:VIBRANT HOLDINGS LLC
    摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

    专利号:WO-0050448-A1
    优先权日:1999-02-26
    标 题 :A method for controlling an enzymatic reaction by the alpha and beta domains of metallothionein
    发明人:VALLEE BERT L; MARET WOLFGANG; FISCHER EDMOND H
    权利人:VALLEE BERT L; MARET WOLFGANG; FISCHER EDMOND H
    摘要:The present invention relates to the alpha and beta domains of metallothionein and analogs thereof, their synthesis, and methods for controlling in vitro and industrial enzymatic reactions using them. Purified metal-free and metal-containing alpha and beta domains of metallothionein and analogs thereof are provided as described below. A high yield method of synthesis and purification is also provided for the metal-free and metal containing alpha and beta domains of metallothionein and analogs thereof. Finally, methods for controlling in vitro and industrial enzymatic reactions are provided wherein the enzymatic processes are controlled by transfer or removal of a metal cation, to or from an enzyme metal-inhibitory site using the alpha and beta domains of metallothionein and analogs thereof.

    专利号:US-6090912-A
    优先权日:1993-05-27
    标 题:Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond
    发明人:LEBL MICHAL; LAM KIT S; SALMON SYDNEY E; KRCHNAK VICTOR; SEPETOV NIKOLAI; KOCIS PETER
    权利人:SELECTIDE CORP
    摘要:The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

    专利号:US-5840485-A
    优先权日:1993-05-27
    标题 :Topologically segregated, encoded solid phase libraries
    发明人:LEBL MICHAL; LAM KIT S; SALMON SYDNEY E; KRCHNAK VICTOR; SEPETOV NIKOLAI; KOCIS PETER
    权利人:SELECTIDE CORP
    摘要:The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.

    专利号:CN-120192252-A
    优先权日:2025-02-24
    标 题 :Synthesis method of key intermediate of itracin

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/acs.jmedchem.9b02119
    摘要:Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C. Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin. J Med Chem. 2020 Aug 13;63(15):8231–49. doi: 10.1021/acs.jmedchem.9b02119.
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