专利号:US-12251674-B2 优先权日:2012-11-14 标 题:Substrates, systems, and methods for array synthesis and biomolecular analysis 发明人:RAJASEKARAN JOHN J; JAYARAMAN VASANTH; WANG TIANHAO; BEI KANG; KRISHNAMURTHY HARI KRISHNAN; VEDANTHAM PUNITHA 权利人:VIBRANT HOLDINGS LLC 摘要:Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N→C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
专利号:WO-0050448-A1 优先权日:1999-02-26 标 题 :A method for controlling an enzymatic reaction by the alpha and beta domains of metallothionein 发明人:VALLEE BERT L; MARET WOLFGANG; FISCHER EDMOND H 权利人:VALLEE BERT L; MARET WOLFGANG; FISCHER EDMOND H 摘要:The present invention relates to the alpha and beta domains of metallothionein and analogs thereof, their synthesis, and methods for controlling in vitro and industrial enzymatic reactions using them. Purified metal-free and metal-containing alpha and beta domains of metallothionein and analogs thereof are provided as described below. A high yield method of synthesis and purification is also provided for the metal-free and metal containing alpha and beta domains of metallothionein and analogs thereof. Finally, methods for controlling in vitro and industrial enzymatic reactions are provided wherein the enzymatic processes are controlled by transfer or removal of a metal cation, to or from an enzyme metal-inhibitory site using the alpha and beta domains of metallothionein and analogs thereof.
专利号:US-6090912-A 优先权日:1993-05-27 标 题:Topologically segregated, encoded solid phase libraries comprising linkers having an enzymatically susceptible bond 发明人:LEBL MICHAL; LAM KIT S; SALMON SYDNEY E; KRCHNAK VICTOR; SEPETOV NIKOLAI; KOCIS PETER 权利人:SELECTIDE CORP 摘要:The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.
专利号:US-5840485-A 优先权日:1993-05-27 标题 :Topologically segregated, encoded solid phase libraries 发明人:LEBL MICHAL; LAM KIT S; SALMON SYDNEY E; KRCHNAK VICTOR; SEPETOV NIKOLAI; KOCIS PETER 权利人:SELECTIDE CORP 摘要:The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided. The invention also relates to methods of synthesizing such libraries and the use of such libraries to identify and characterize molecules of interest from among the library of synthetic test compound.
专利号:CN-120192252-A 优先权日:2025-02-24 标 题 :Synthesis method of key intermediate of itracin
参考文献:10.1021/acs.jmedchem.9b02119 摘要:Dubois L, Pietrancosta N, Cabaye A, Fanget I, Debacker C, Gilormini PA, Dansette PM, Dairou J, Biot C, Froissart R, Goupil-Lamy A, Bertrand HO, Acher FC, McCort-Tranchepain I, Gasnier B, Anne C. Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin. J Med Chem. 2020 Aug 13;63(15):8231–49. doi: 10.1021/acs.jmedchem.9b02119.