CAS: 52939-33-0; (S)-3-(4-Methoxyphenyl)-2-(Methylamino)Propanoic Acid

上下游产品

bromo-(4-methoxy-benzyl)-malonic acid 5-(4-methoxy-benzyl)-1,3-dimethyl-imidazolidine-2,4-dione 2-(4-methoxybenzylidene)malonic acid 2-(4-methoxybenzyl)malonic acidN-methyltyrosine (+)-(S)-methyl 3-(3,5-dibromo-4-methoxyphenyl)-2-methylaminopropanoate (+)-(S)-3-(3,5-dibromo-4-methoxyphenyl)-2-methylaminopropanoic acid hydr°Chloride

(S)-2-(Tert-Butoxycarbonyl(Methyl)Amino)-3-(4-Methoxyphenyl)Propanoic Acid置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,以100%的收率获得产物n,O-二甲基-L-酪氨酸
参考文献:Pompanopeptins A And B,New Cyclic Peptides From The Marine Cyanobacterium Lyngbya Confervoides
标题:Pompanopeptins A And B,New Cyclic Peptides From The Marine Cyanobacterium Lyngbya Confervoides
摘要:A New 3-Amino-6-Hydroxy-2-Piperidone (Ahp) Containing Peptolide,Pompanopeptin A (1),And A Novel N-Methyl-2-Amino-6-(4'-Hydroxyphenyl)Hexanoic Acid (N-Me-Ahpha) Containing Cyclic Pentapeptide Connected With A Sixth Amino Acid Residue Via A Rare Ureido Linkage,Pompanopeptin B (2),Were Isolated From The Marine Cyanobacterium Lyngbya Confervoides Collected From The Southeastern Coast Of Florida. Their Planar Structures Were Determined By A Combination Of NMR Spectroscopic Analysis And Mass Spectrometry. The Absolute Configurations Were Established Using Advanced Marfey'S Method And Chiral HPLC Analysis Of The Chemical Degradation Products. Compound 1 Selectively Inhibited Trypsin Over Elastase And Chymotrypsin,With An Ic(50) Value Of 2.4 Mu M; Selectivity Is Conferred By An Arginine Residue In The Cyclic Core. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2008.02.035

专利信息

专利号:US-2014275533-A1
优先权日:2013-03-15
标题:Methods of Manufacture and Synthesis of Amino Acid Linking Groups Conjugated To Compounds Used For Targeted Imaging of Tumors

专利号:WO-2014149073-A1
优先权日:2013-03-15
标 题:Methods of manufacture and synthesis of amino acid linking groups conjugated to compounds used for targeted imaging of tumors

专利号:US-9789208-B2
优先权日:2013-03-15
标 题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
发明人：KULARATNE SUMITH A
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.

专利号:EP-2968614-B1
优先权日:2013-03-15
标 题:Methods of manufacture and synthesis of amino acid linking groups conjugated to compounds used for targeted imaging of tumors

专利号:US-9782497-B2
优先权日:2013-03-15
标 题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors

专利号:US-2016011199-A1
优先权日:2013-03-15
标 题:Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors