CAS: 52188-06-4; Ethyl 3-(P-Tolyl)Propiolate

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ethanol 3-(4-methylphenyl)prop-2-ynoic acid 4-tolyl iodide ethyl (tributylstannyl)propiolateDimethyloxosulfonium-3-ethoxycarbonyl-2-(p-tolyl)-allylid p-tolyl-[1,3]thiazin-4-one2-amino-6-p-tolyl-[1,3]thiazin-4-one 7,10-Diethyl-9-p-tolyl-fluoranthene-8-carboxylic acid ethyl ester 7,10-Dipropyl-9-p-tolyl-fluoranthene-8-carboxylic acid ethyl ester

📜对溴甲苯置于盐酸,双(乙腈)氯化钯(II),Caesium Carbonate,2-二环己基磷-2,4,6-三异丙基联苯体系中,用 1,4-二氧六环,乙醇,水 作为反应溶剂,化学反应 41.0H,反应生成 乙基3-(4-甲基苯基)-2-丙炔酸酯
参考文献:A Parallel Approach To 7-(Hetero)Arylpyrazolo[1,5-A]Pyrimidin-5-Ones
标题:A Parallel Approach To 7-(Hetero)Arylpyrazolo[1,5-A]Pyrimidin-5-Ones
摘要:A Modular,Two-Pot Assembly Of 7-Arylpyrazolo[1,5-A]Pyrimidones From Aryl/heteroaryl Halides And Aminopyrazoles In Library Format Was Developed. Sonogashira Coupling Of Aryl Bromides With Triethyl Orthopropiolate,Followed By In Situ Orthoester Hydrolysis,Provides Access To Beta-Aryl Ynoates,Which Undergo Regioselective Cyclocondensation With Aminopyrazoles. The Ability To Vary The C7 Vector Of 7-Arylpyrazolo[1,5-Cdpyrimidones In Two Steps Using Readily Available (Hetero)Aryl Halides Significantly Enhances Synthetic Access To This Challenging Vector.
DOI:10.1021/acscombsci.8B00032