CAS: 500-08-3; Forminitrazole

该化合物是一种硝基替代硫化物衍生物,可能用于制药和农用化学研究,其结构特征,包括硝基甲基亚摩化物组和成式氨化物功能,使其成为生物活性化合物合成中的宝贵中间体;适合进一步功能化的复合物物证反应,能够开发新型的乙型环环化衍生物;在标准条件下的稳定性和明确界定的化学特性有利于其在受控合成途径的使用;研究人员可以探索其在抗微生物或抗寄生物剂开发中的效用,因为硝基硫酸盐的药价价值很大;该化合物通常在受控制的实验室条件下处理,以确保实验应用的纯度和一致性.

英文名称Forminitrazole
中文名称福米硝唑
IUPAC名称N-(5-nitrothiazol-2-yl)formamide
其它别名N-(5-Nitrothiazol-2-yl)Formamide; N-(5-Nitro-1,3-Thiazol-2-yl)Formamide; N-(5-Nitro-1,3-Thiazol-2-yl)Methanamide; Forminitrazole; Formamide, N-(5-Nitro-2-Thiazolyl)-; Forminitrazole Usp/ep/bp
CAS编号500-08-3
MFCD编号:MFCD00866797
FDA UNII编号:GTW8DB3OVN
分子式:C4H3N3O3S分子量:173.15
产品CID: 1486544
产品分类原料药 → 抗寄生虫病药 → 抗阿米巴病及抗滴虫病药

相似结构搜索
产品信息参考;;
InChIKey: ODLJCVGAFRZOOB-UHFFFAOYSA-N
InChI=1S/C4H3N3O3S/c8-2-6-4-5-1-3(11-4)7(9)10/h1-2H,(H,5,6,8)
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数1.0

MSDS等安全信息

警示词Warning
危险描述H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

CAS号121-66-4 2-氨基-5-硝基噻唑 | CAS号2258-42-6 甲乙酐 | CAS号64-18-6 甲酸

合成工艺路线路线简述

📜2-氨基-5-硝基噻唑,甲乙酐以乙醚作为反应溶剂,以465 Mg的收率获得产物福米硝唑
参考文献:A Fluorous And Click Approach For Screening Potential Pet Probes: Evaluation Of Potential Hypoxia Biomarkers
标题:A Fluorous And Click Approach For Screening Potential Pet Probes: Evaluation Of Potential Hypoxia Biomarkers
摘要:Radiopharmaceuticals For Nuclear Imaging Are Essentially Targeting Molecules,Labeled With Short-Lived Radionuclides (E. G.,F-18 For Pet). A Significant Drawback Of Radiopharmaceuticals Development Is The Difficulty To Access Radiolabeled Molecule Libraries For Initial In Vitro Evaluation,As Radiolabeling Has To Be Optimized For Each Individual Molecule. The Present Paper Discloses A Method For Preparing Libraries Of F-18-Labeled Radiopharmaceuticals Using Both The Fluorous-Based F-18-Radiochemistry And The Huisgen 1,3-Dipolar (Click) Conjugation Reaction. As A Proof Of Concept,This Approach Allowed Us To Obtain A Series Of Readily Accessible F-18-Radiolabeled Nitroaromatic Molecules,For Exploring Their Structure-Activity Relationship And Further In Vitro Evaluation Of Their Hypoxic Selectivity. Crown Copyright (C) 2011 Published By Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2011.10.084