CAS: 4727-40-6; S-Methylmethionine

📜L-蛋氨酸,S-腺苷蛋氨酸置于his6-Methyltransferase体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 1.5H,反应生成 S-甲基-L-蛋氨酸
参考文献:Ed酸加载到一条不寻常的硫模板生产线上,构建了伯克霍尔德菌毒力因子的环丙醇战斗部.
标题:Ed酸加载到一条不寻常的硫模板生产线上,构建了伯克霍尔德菌毒力因子的环丙醇战斗部.
摘要:假伯克霍尔德氏菌的致病菌该组引起严重的传染病,例如腺体和类瘤病.malleicyprols被确定为重要的细菌毒力因子,但其环丙醇战斗部的生物合成起源仍是一个谜.通过突变分析和代谢组学的结合,我们发现sulf酸,丙二酸二甲基ulf(dmsp)和go香酚,是渗透压剂,是全球有机硫循环中的关键成分,是通往环丙醇装置的关键中间体.功能遗传学和体外分析揭示了一种涉及稀有甲基化的,涉及罕见的原核set域甲基转移酶的dmsp专门途径,并表明dmsp通过专用于两性离子起始剂单元的腺苷酸化域被加载到nrps-Pks杂化装配线上.然后,大合酶将dmsp转化为凉拌酚,大肠杆菌.
DOI:10.1002/anie.202003958

专利信息

专利号:US-2007167530-A1
优先权日:2003-12-23
标 题:Method for depletion of sulphur and/or compounds containing sulphur from a biochemically produced organic compound
发明人：GERLACH TILL; MELDER JOHANN-PETER; HOFFER BRAM W; MEIER ANTON
权利人:BASF AG
摘要:Method of reducing the concentration of sulfur and/or a sulfur-containing compound in a biochemically prepared organic compound by bringing the respective organic compound into contact with an adsorbent. Ethanol which has a particular specification and can be prepared by the abovementioned method, and its use as solvent, disinfectant, as component in pharmaceutical or cosmetic products or in foodstuffs or in cleaners, as feed in steam reforming processes for the synthesis of hydrogen or in fuel cells, or as building block in chemical synthesis.

专利号:US-7452701-B2
优先权日:1998-11-24
标 题:Methods for the preparation of β-amino acids
发明人：FREY PERRY A; RUZICKA FRANK J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Purified β-amino acids are of considerable interest in the preparation of pharmacologically active compounds and industrial precursors. Although enantiomerically pure β-amino acids can be produced by standard chemical synthesis, this traditional approach is time consuming, requires expensive starting materials, and results in a racemic mixture which must be purified further. However, DNA molecules encoding lysine 2,3-aminomutase can be used to prepare β-amino acids by methods that avoid the pitfalls of chemical synthesis. The present invention provides a method of producing enantiomerically pure β-amino acids from α-amino acids comprising catalyzing the conversion of an α-amino acid to a corresponding β-amino acid by utilizing a lysine 2,3-aminomutase as the catalyst.

专利号:US-5922335-A
优先权日:1995-05-15
标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
发明人：PTCHELINTSEV DMITRI
权利人:AVON PROD INC
摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.

专利号:US-7635764-B2
优先权日:1997-11-24
标题:Nucleic acid molecules associated with the methionine synthesis and degradation pathways
发明人：BLEDIG STEFAN A; BYRUM JOSEPH R; LIU JINGDONG
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention is in the field of plant biochemistry. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, DNA sequences from maize and soybean plants associated with the methionine pathway. The invention encompasses nucleic acid molecules that encode proteins and fragments of proteins. In addition, the invention also encompasses proteins and fragments of proteins so encoded and antibodies capable of binding these proteins or fragments. The invention also relates to methods of using the nucleic acid molecules, proteins and fragments of proteins and antibodies, for example for genome mapping, gene identification and analysis, plant breeding, preparation of constructs for use in plant gene expression and transgenic plants.

专利号:US-8927485-B2
优先权日:2010-02-18
标题:Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides
发明人：KRANTZ ALEXANDER; YU PENG
权利人:KRANTZ ALEXANDER; YU PENG; ADVANCED PROTEOME THERAPEUTICS INC
摘要:The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.

专利号:TW-201518323-A
优先权日:2013-07-25
标题 :Synthesis of biological conjugates of APELIN polypeptides