CAS: 4714-62-9; 4-(Methylamino)Benzonitrile

上下游产品

N-methyl-N-(4-cyanophenyl)nitrous amide N-(4-cyanophenyl)-N-methylacetamide styrene 4-cyano-N,N-dimethylaniline-N-oxide 4-methylamino-benzamidine N-(4-cyanophenyl)-N-methylcarbamoyl chloride N-(4-cyanophenyl)-N-methylformamide p-cyano-N-methylaniline ethyl carbamate

对氨基苯腈置于甲醇,Sodium Tetrahydroborate,Sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 18.0H,反应生成 N-甲基-4-氰基苯胺
参考文献:Direct Condensation Of Functionalized Sp3 Carbons With Formanilides For Enamine Synthesis Using An In Situ Generated Hmds Amide Catalyst
标题:Direct Condensation Of Functionalized Sp3 Carbons With Formanilides For Enamine Synthesis Using An In Situ Generated Hmds Amide Catalyst
摘要:使用在场反应生成的hmds酰胺碱通过氨基硅烷和氟化盐的组合合成了包括β-烯胺酯在内的官能化恩酰胺.
DOI:10.1039/c4Cc02228A

专利信息

专利号:US-9533971-B2
优先权日:2012-10-29
标 题 :Process for the synthesis of dabigatran and its intermediates
发明人：PULLAGURLA MANIK REDDY; RANGISETTY JAGADEESH BABU; NANDAKUMAR MECHERIL VALSAN
权利人:BIOPHORE INDIA PHARMACEUTICALS PVT LTD; BIOPHORE INDIA PHARMACEUTICALS PVT LTD
摘要:The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:US-8846898-B2
优先权日:2000-10-17
标题:Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotide having reduced internucleotide charge
发明人：DELLINGER DOUGLAS J
权利人:DELLINGER DOUGLAS J; Lieure Cornu LLC
摘要:Nucleoside phosphinoamidite carboxylates and analogs are provided that have the structure of formula (III) n nwherein A is hydrogen, hydroxyl, lower alkoxy, lower alkoxy-substituted lower alkoxy, halogen, SH, NH 2 , azide or DL wherein D is O, S or NH and L is a heteroatom-protecting group, unsubstituted hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, or substituted heteroatom-containing hydrocarbyl; B is a nucleobase; and one of R 11 and R 12 is a blocking group and the other is (IV) or (VI)n n nin which W, X, Y, Z, R 1 and n are as defined herein.

专利号:US-2010311960-A1
优先权日:2000-10-17
标 题 :Phosphinoamidite Carboxylates and Analogs Thereof in the Synthesis of Oligonucleotide Having Reduced Internucleotide Charge

专利号:US-2006293511-A1
优先权日:2000-10-17
标 题:Phosphinoamidite carboxylates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge

专利号:US-2015246900-A1
优先权日:2012-10-29
标题 :Process for the Synthesis of Dabigatran and Its Intermediates