CAS: 4532-96-1; 1-Isopropyl-1H-Imidazole

相似化合物

15469-97-3 45676-04-8 139143-09-2

上下游产品

CAS号50-00-0 甲醛 | CAS号75-31-0 异丙胺 | CAS号288-32-4 咪唑 | CAS号75-30-9 2-碘代丙烷 | CAS号75-26-3 2-溴丙烷 | CAS号119171-19-6 1-methyl-3-prop... | CAS号84606-45-1 1-异丙基-2-甲基咪唑 | CAS号429641-40-7 1,3-di(propan-2... | CAS号468081-82-5 2-[(1-propan-2-... | CAS号53332-64-2 1-异丙基-1H-咪唑-2-甲醛

1-(2-Cyano-Ethyl)-3-Isopropyl-3H-Imidazol-1-Ium; Bromide置于sodium Hydroxide体系中,化学反应 0.67H,反应生成 1-异丙基咪唑
参考文献:Hofmann-Type Elimination In The Efficientn-Alkylation Of Azoles: Imidazole And Benzimidazole
标题:Hofmann-Type Elimination In The Efficientn-Alkylation Of Azoles: Imidazole And Benzimidazole
摘要:开发了一种简便高效的1-取代1H-氮杂环(咪唑和苯并咪唑)的制备方法,该方法涉及从卤化物与1H-咪唑-1-丙腈和1H-苯并咪唑-1-丙腈反应得到的氮杂环盐中选择性霍夫曼型消除2-氰乙基.整体产率依次为:伯烷基卤化物 >= 烯丙基卤化物 >= 仲烷基卤化物 > 苄基卤化物 > α-酮卤化物(与烷基化剂相关),以及咪唑 > 苯并咪唑(与氮杂环相关).
DOI:10.1055/s-1994-25414

专利信息

专利号:US-2012165520-A1
优先权日:2010-12-23
标题:Process for the synthesis of prodrugs of opioids
发明人：MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
权利人:MCGEE PAUL; GARNETT IAN; JUAN E; MANAGE A; CARNIAUX JEAN-FRANCOIS
摘要:The present invention provides a process for the synthesis of opioid prodrugs. In particular, the present invention provides a process for the synthesis of opioid prodrugs comprising: treating an opioid, in the form of a salt or a freebase, with a carbonyl synthon to form an activated intermediate and subsequently reacting the activated intermediate with an amine, in the form of a salt or a freebase.

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:US-7173059-B2
优先权日:2003-05-08
标题:Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same
发明人：ALBIZATI KIM FRANCIS; BABU SRINIVASAN
权利人:AGOURON PHARMA
摘要:Optically active 3-amino-butene and 1,2-dihydroxy-3-amino-butane intermediate compounds, useful in the synthesis of HIV-protease inhibitors and methods of preparing these intermediate compounds are disclosed.

专利号:US-8637695-B2
优先权日:2011-12-30
标 题:Synthesis of organohalosilane monomers from conventionally uncleavable Direct Process Residue
发明人：LEWIS KENRICK MARTIN; NEELY JOHN DAVID
权利人:LEWIS KENRICK MARTIN; NEELY JOHN DAVID; MOMENTIVE PERFORMANCE MAT INC
摘要:Disclosed herein is a catalytic process for the synthesis of organohalosilane monomers from tetraorganodihalodisilanes and other compounds that are not cleaved during the conventional hydrochlorination of Direct Process Residue. The process is characterized by the use of a catalyst containing (1) one or more heterocyclic amines and/or one or more heterocyclic ammonium halides, and (2) one or more quaternary Group 15 onium compounds.

专利号:US-6472534-B2
优先权日:1999-10-21
标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
发明人：BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K
权利人:AGOURON PHARMA
摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.

专利号:US-11708381-B2
优先权日:2016-11-25
标题:Inhibitors of androgen receptor signaling
发明人：WANG GUANGDI; LIU JIAWANG; ZHENG SHILONG; GUO SHANCHUN
权利人:XAVIER UNIV OF LOUISIANA
摘要:The present disclosure relates to androgen receptor signaling inhibitors and the synthesis of the same. Further, the present disclosure teaches the utilization of the androgen receptor signaling inhibitors in a treatment for proliferative diseases, including cancer, particularly prostate cancer, and especially castration-resistant prostate cancer.