CAS: 4021-11-8; 2-Methylisonicotinic Acid

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2,4-二甲基吡啶置于吡啶,Selenium(Iv) Oxide体系中,化学反应 1.0H,反应生成 2-甲基-4-羧基吡啶
参考文献:2'联芳酰胺作为新型和亚型选择性m 1激动剂.第一部分:识别,合成和初始sar
标题:2'联芳酰胺作为新型和亚型选择性m 1激动剂.第一部分:识别,合成和初始sar
摘要:发现联芳基酰胺是新型和亚型的选择性m 1毒蕈碱乙酰胆碱受体激动剂.描述了导致化合物3J和4C的鉴定,合成和初始结构-活性关系,它们具有非常好的m 1激动剂效力和内在活性,以及m 1相对于m 2-5的亚型选择性.
DOI:10.1016/j.Bmcl.2010.04.128

专利信息

专利号:US-2010234339-A1
优先权日:2007-05-31
标 题 :Silver(i) compounds and their use in pharmaceutical compositions for the treatment,prophylaxis and prevention of infections
发明人：OEHRSTROEM LARS; LANGER VRATISLAV; ABU-YOUSSEF MORSY A M; YOURSY GOHAR; MASSOUD ALSHIMA A A
权利人:CSE INCUBATION AB
摘要:The present invention provides new Ag(I) complexes with derivatives of nicotinic acid, nicotinamide and related pyridine ligands, and pharmaceutical compositions comprising such Ag(I) complexes for use in the treatment, prophylaxis and prevention of infections. The invention further provides a solvent free method for the synthesis of Ag(I) complexes containing substituted pyridines, pyrazines and pyrimidines as ligands.

专利号:US-9938278-B2
优先权日:2014-12-17
标题 :FXR (NR1H4) modulating compounds
发明人：GEGE CHRISTIAN; KREMOSER CLAUS; KINZEL OLAF; BLOMGREN PETER A; CURRIE KEVIN S; KROPF JEFFREY E; SCHMITT AARON C; WATKINS WILLIAM J; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-9820979-B2
优先权日:2011-07-13
标 题:FXR (NR1H4) binding and activity modulating compounds
发明人：KINZEL OLAF; STEENECK CHRISTOPH; KREMOSER CLAUS
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-9751874-B2
优先权日:2014-12-17
标题:Hydroxy containing FXR (NR1H4) modulating compounds
发明人：GEGE CHRISTIAN; KINZEL OLAF; KREMOSER CLAUS; SCHMITT AARON C
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-4093622-A
优先权日:1975-05-19
标题 :Pyridine esters of cyclopropane-carboxylic acid
发明人：HENRICK CLIVE A; STAAL GERARDUS B
权利人:ZOECON CORP
摘要:Heterocyclic organic esters and thioesters characterized by the presence of one or two cyclopropane moieties, synthesis thereof, and compositions thereof for the control of mites and ticks.

专利号:US-8361516-B2
优先权日:2006-08-03
标 题:Composition comprising sarsasapogenin
发明人：LINTNER KARL; MAS CHAMBERLIN CLAIRE
权利人:SEDERMA SA; LINTNER KARL; MAS CHAMBERLIN CLAIRE
摘要:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.