CAS: 40127-89-7; 2-Amino-3-Cyano-5-Chloromethylpyrazine-1-Oxide

专利信息

专利号:US-5698556-A
优先权日:1995-06-07
标题 :Methotrexate analogs and methods of using same
发明人：CHAN CARCY L
摘要:The present invention provides methotrexate analogs having the formula: +TR wherein R is methyl or hydro, X is halo or hydro, and D1 is -NR1R2 wherein either both R1 and R2 are hydrogen, or one is hydrogen and the other is C1-C5 alkyl, C1-C5 haloalkyl, cyano C1-C5 alkyl, C1-C5 hydroxyalkyl, alkoxyalkyl wherein the alkoxy and the alkyl have 1-5 carbon atoms, carboxy C1-C5 alkyl, phenyl, C1-C5 alkyl phenyl, C(=O)R' wherein R' is hydrogen, C1-C5 alkyl, phenyl, or C1-C5 alkyl phenyl, C(=O)OR'' wherein R'' is hydrogen, C1-C5 alkyl, phenyl, or C1-C5 alkyl phenyl, amino, C(=NH)NH2, C(=O)NH2, or C(=S)NH2, and structurally related derivatives, as well as pharmaceutical compositions comprising such MTX analogs, methods of synthesis of the MTX analogs, and use of the MTX analogs in modulating cellular functions, or in treating cancer and other diseases or disorders capable of being treated using MTX.

专利号:US-5382582-A
优先权日:1993-03-26
标题:Methotrexate analogs and methods of using same
发明人：CHAN CARCY L
摘要:The methotrexate analogs 7-d-MTX, 7,9,9-d3-MTX, MTX halogenated or possessing some other such group at the 7-position capable of reducing oxidation to 7-OH-MTX, and structurally related analogs, as well as pharmaceutical compositions containing the analogs, the synthesis of the MTX analogs, and use of the analogs in modulating cellular function.