CAS: 39791-20-3; (8R,9S,13S,14S,16R,17R)-3-(Cyclopentyloxy)-17-Ethynyl-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6H-Cyclopenta[a]Phenanthrene-16,17-Diol
该化合物是一种合成类类类化合物,即种状物,主要特征是其结构与自然激素,特别是蛋白质的相似性;尼尔斯特里醇的外观活动209518年;尼尔斯特里醇,它可以模仿体内孕酮的影响,影响各种生理过程,如月经周期和妊娠维持;该化合物经常被研究,以其可能用于激素替代疗法和某些妇科病治疗的治疗用途;尼罗斯特里醇通常以药物形式施用,其功效和安全特征通过临床研究加以评估;与许多合成激素一样,它可能具有副作用和反作用,因此需要仔细考虑其使用;总的来说,尼罗特里醇是内分泌学和生殖健康领域的一个重要化合物,有助于理解和管理荷尔蒙疗法.
- 英文名称(8R,9S,13S,14S,16R,17R)-3-(Cyclopentyloxy)-17-Ethynyl-13-Methyl-7,8,9,11,12,13,14,15,16,17-Decahydro-6H-Cyclopenta[a]Phenanthrene-16,17-Diol
- 中文名称尼尔雌醇
- IUPAC名称(8R,9S,13S,14S,16R,17R)-3-(cyclopentyloxy)-17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
- 其它别名Nilestriolum [inn-Latin] | 19-Nor-17-Pregna-1,3,5(10)-Trien-20-Yne-16,17-Diol, 3-(Cyclopentyloxy)-, (16Alpha,17Alpha)- | 19-Nor-17-Pregna-1,3,5(10)-Trien-20-Yne-16,17-Diol, 3-(Cyclopentyloxy)-, (16.Alpha.,17.Alpha.)- | 3-(Cyclopentyloxy)-17Alpha-Ethinyl-1
- CAS编号39791-20-3
- MFCD编号:MFCD00867390
- FDA UNII编号:7JA3B3IALU
- 分子式:C25H32O3分子量:380.53
- 产品CID: 1409694
- 产品分类原料药 → 激素及调节内分泌功能类药 → 雌激素及孕激素类药
物理性质
- 熔点162-165 °C(溶剂: ethyl ether (60-29-7); hexane (110-54-3))
- 沸点521.7±50.0 °C at 760 mmHg
- 闪点269.3±30.1 °C
- 密度1.2±0.1 g/cm3
- pKa:12.57±0.60(预测)
- PSA:49.69
- LogP:5.74
- 折射率1.612
- 蒸汽压0.0±1.4 mmHg at 25°C
- 外观形态白色至类白色固体
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用雌激素类药,用于治疗因雌激素缺乏而引起的更年期缩合症.
上下游产品
trimethylsilylacetylene (trimethylsilyl)ethynylmagnesium bromide 19-hydroxy-4-androstene-3,17-dione 19-acetoxyandrosta-1,4-diene-3,17-dione合成工艺路线路线简述
📜在 高氯酸,Potassium Carbonate体系中,用 乙醇,丙酮 用作溶剂,化学反应 13.33H,反应生成尼尔雌醇
参考文献:一种尼尔雌醇的制备方法
标题:一种尼尔雌醇的制备方法
摘要:本发明提供一种尼尔雌醇的制备方法,以乙炔化物作为起始原料,先与有机酮类进行缩酮反应,再分离出17β‑乙炔化物异构体,再精制得到纯度较高的17A‑乙炔化物,再与溴代环戊烷发生醚化反应得到尼尔雌醇粗品,精制后得到尼尔雌醇精品.与现有技术相比,本发明的制备方法能够制备得到高纯度的尼尔雌醇精品,且从源头上精制了原料,简化了尼尔雌醇的制备工艺,产率高,显著提高了反应经济性,降低了生产成本.
海关参考信息
- 2901292000-乙炔
2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-109721634-A
优先权日:2019-01-24
标题:A kind of synthesis technique of Nilestriol
专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
专利号:CN-1765918-A
优先权日:2005-11-25
标 题 :The high alkynes estradiol of 17a α-D--3-ethyl ester and synthesis preparation method thereof and be the pharmaceutical composition of activeconstituents with this compound
专利号:CN-109721634-B
优先权日:2019-01-24
标 题:Synthesis process of nilestriol
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Li XF, Lin CB, Xie FR, Liang WG, Ji J, Yang Y. Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats. Am J Ther. 2016 Nov/Dec;23(6):e1630-e1636. doi: 10.3969/j.issn.1672-7347.2010.12.008. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. Chinese. doi: 10.3892/mmr.2015.3551. Epub 2015 Mar 26.
20: Nian H, Ma MH, Nian SS, Xu LL. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine. 2009 Apr;16(4):320-6. doi: 10.1016/j.phymed.2008.12.006. Epub 2009 Mar 6.
合成参考文献
摘要:Ma QL, Zhou HY, Sun M. [Relationship between sex hormone levels and blood calcitonin gene-related peptide/endothelin-1 in postmenopausal women with coronary heart disease]. Hunan Yi Ke Da Xue Xue Bao. 2001 Apr 28;26(2):146–8.
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