CAS: 38966-21-1; (3R,4R,4Ar,6As,8R,9R,11As,11Bs)-4,9-Bis(Hydroxymethyl)-4,11B-Dimethyltetradecahydro-8,11A-Methanocyclohepta[a]Naphthalene-3,9-Diol

上下游产品

CAS号121741-50-2 3α,18-isopropyl... | CAS号116446-56-1 [17-14C]-3α,16β... | CAS号52592-12-8 APHIDICOLIN DIA... | CAS号121741-51-3 methyl 3α,18-is... | CAS号101143-85-5 aphidicolan-16β-ol | CAS号82026-04-8 3α-acetoxy-16,1... | CAS号82026-03-7 8,11a-Methano-1... | CAS号82026-06-0 aphidicolin, 3-keto | CAS号82026-05-9 8,11a-Methano-1... | CAS号52645-92-8 APHIDICOLIN, 3-EPI | CAS号82026-07-1 6-.beta.-Hydrox...

📜3α,18-Dihydroxyaphidicolane置于cephalosporium Aphidicola,Tween-80体系中,用 乙醇,二甲基亚砜 作为反应溶剂,化学反应 480.0H,以475 Mg的收率获得产物艾菲地可宁
参考文献:二萜类蚜虫生物合成中c-17位羟基化
标题:二萜类蚜虫生物合成中c-17位羟基化
摘要:Aphidicolin 生物合成中 C-17 处的羟基化被 17-硫醇抑制.从 3α,18-Dihydroxy-15β,16β-Methanoaphidicolane 获得在 C-17 处羟基化并保留环丙烷环的代谢物,而当这些底物与真菌 Cephalosporium Aphidicola 孵育时,Aphidicolin 本身是从 3α,18-Dihydroxyaphidicola 获得的.
DOI:10.1016/s0031-9422(96)00713-3

专利信息

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2012149888-A1
优先权日:2009-02-22
标 题:Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
权利人:SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
摘要:The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1, bearing ara-2′-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents.

专利号:US-2013122562-A1
优先权日:2011-08-04
标 题:Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
发明人：ALDOR ILANA S; BECK ZACHARY Q; MILLER MICHAEL C; PERES CAROLINE M
权利人:ALDOR ILANA S; BECK ZACHARY Q; MILLER MICHAEL C; PERES CAROLINE M; DANISCO US INC
摘要:This invention relates to a recombinant microorganism capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, the acetoacetyl-CoA synthase gene encoding an enzyme capable of synthesizing acetoacetyl-CoA from malonyl-CoA and acetyl-CoA and one or more genes involved in isoprene biosynthesis that enables synthesis of isoprene from acetoacetyl-CoA are introduced into a host microorganism.

专利号:US-2022162188-A1
优先权日:2019-01-15
标 题:Isoprenoids and methods of making thereof
发明人：WILLIAMS GAVIN; LUND SEAN; HALL RACHAEL
权利人:UNIV NORTH CAROLINA STATE
摘要:Disclosed are methods for preparing isoprenoid subunits, as well as methods of employing these isoprenoid subunits for the synthesis of isoprenoids. Also provided are isoprenoids prepared using the methods described herein.

专利号:US-9211296-B2
优先权日:2007-02-06
标题:Therapeutic compounds for blocking DNA synthesis of POX viruses
发明人：RICCIARDI ROBERT P
权利人:UNIV PENNSYLVANIA
摘要:This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula I, formula XXI, formula XXXII, or formula XLI which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula I, formula XXI, formula XXXII, or formula XLI can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.