CAS: 3868-32-4; 8-Aminoguanosine
该化合物是一种核素-6H-6-purin-6-one,对于其在生物系统中的作用至关重要,特别是在RNA合成中. 纯树环的二氢形式表明,它可能与其完全芳香的对应方相比,具有不同的反应性和稳定性.该化合物对医药化学和生物化学和生物化学具有兴趣,因为它可能被用于抗病毒和抗癌疗法,从而干扰核酸新陈代谢.
- 英文名称8-Aminoguanosine
- 中文名称8-氨基鸟嘌呤核苷
- IUPAC名称2,8-diamino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,9-dihydro-6H-purin-6-one
- 其它别名2,8-Diaminoinosine; 8-Aminoguanosine; 2,8-Diamino-9-(3,4-Dihydroxy-5-Methylol-Tetrahydrofuran-2-yl)-3H-Purin-6-One; 2,8-Diamino-9-[3,4-Dihydroxy-5-(Hydroxymethyl)-2-Tetrahydrofuranyl]-3H-Purin-6-One; 2,8-Diamino-9-[3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-3H-Purin-6-One; 2,8-Diamino-9-[3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl]-1,9-Dihydro-6H-Purin-6-One; 2,8-Diamino-9-[3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl]-3H-Purin-6-One; 8-Amino-D-Guanosine
- CAS编号3868-32-4
- MFCD编号:MFCD00036759
- FDA UNII编号:SHO2CA1BRO
- 分子式:C10H14N6O5分子量:298.26
- 产品CID: 1399042
- 产品分类有机原料→生命科学→核苷&核苷酸→氨基修饰性核苷
相似化合物
118-00-3 38819-10-2 26578-09-6物理性质
MSDS等安全信息
上下游产品
CAS号118-00-3 鸟苷 | CAS号28128-41-8 8-氨基鸟嘌呤合成工艺路线路线简述
- 合成目标产物 8-Aminoguanosine 主要起始原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
- (文献来源)合成步骤主要原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6797822-B1
优先权日:2000-05-09
标题:Compositions and methods of use of 8-nitroguanine
发明人：HOLWITT ERIC A
权利人:CONCEPTUAL MINDWORKS INC
摘要:Novel methods for the synthesis of 8-nitroguanine are provided. Compositions comprising 8-nitroguanine, made by the novel synthetic methods are also provided herein. Methods of use of 8-nitroguanine, made by the novel synthetic methods, as a standard for detection of 8-nitroguanine in samples are also encompassed within the scope of the present invention. The present invention further concerns methods of predicting organ transplant rejection and detecting exposure to environmental stressors, such as ionizing radiation, toxic chemicals or infectious agents, by detecting 8-nitroguanine in one or more samples from a transplant recipient or an organism exposed to stress.
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合成参考文献
参考文献:10.1016/s0960-894x(02)00064-1
摘要:Alvarez F, Ghérardi A, Nebois P, Sarciron ME, Pétavy AF, Walchshofer N. Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase. Bioorg Med Chem Lett. 2002 Mar 25;12(6):977–9. doi: 10.1016/s0960-894x(02)00064-1.
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