CAS: 34784-07-1; 8-Chloroisoquinoline

相似化合物

73075-61-3 73075-59-9 62882-02-4

上下游产品

m-Chlorobenzaldehyde 2,2-dimethoxyethylamine isoquinoline 5-bromoisoquinoline 8-chloro-5-nitroisoquinoline 2-benzoyl-8-chloro-1-cyano-1,2-dihydroisoquinoline 8-chloro-1-(3,4-dimethoxy-benzyl)-isoquinoline 8-phenyl-1,2,3,4-tetrahydroisoquinoline

N-[(2-Chlorophenyl)Methylene]-2,2-Dimethoxyethanamine置于硫酸体系中,化学反应 0.5H,反应生成 8-氯异喹啉
参考文献:Inhibitors Of Phenylethanolamine N-Methyltransferase And Epinephrine Biosynthesis. 1. Chloro-Substituted 1,2,3,4-Tetrahydroisoquinolines
标题:Inhibitors Of Phenylethanolamine N-Methyltransferase And Epinephrine Biosynthesis. 1. Chloro-Substituted 1,2,3,4-Tetrahydroisoquinolines
摘要:In A Search For Inhibitors Of Epinephrine Biosynthesis As Potential Therapeutic Agents,A Series Of 13 Ring-Chlorinated 1,2,3,4-Tetrahydroisoquinolines Was Prepared. These Compounds Were Tested Initially For Their Ability To Inhibit Rabbit Adrenal Phenylethanolamine N-Methyltransferase (Pnmt) In Vitro. Enzyme-Inhibitor Dissociation Constants,Determined For The Six Most Potent Members Of The Series,Indicated The Following Order Of Decreasing Potency: 7,8-Cl2 Greater Than 6,7,8-Cl3 Greater Than 7-Cl Approximately 5,6,7,8-Cl4 Greater Than 5,7,8-Cl3. These Compounds Were Subsequently Examined For Pnmt-Inhibiting Activity In Intact Rats And Mice. 7,8-Dichloro-1,2,3,4-Tetrahydroisoquinoline (13,Sk&f 64139) Was The Most Potent Member Of The Series Both In Vitro And In Vivo And Is Currently Undergoing Clinical Investigation.
DOI:10.1021/jm00179A007

专利信息

专利号:WO-2007147775-A1
优先权日:2006-06-20
标 题 :Process for synthesis of aromatic compounds
发明人：HUTCHINGS MICHAEL GORDON; QUAYLE PETER; BULL JAMES ALAN; BARROSO CRISTINA LUJAN
权利人:DYSTAR TEXTILFARBEN GMBH & CO; HUTCHINGS MICHAEL GORDON; QUAYLE PETER; BULL JAMES ALAN; BARROSO CRISTINA LUJAN
摘要:The present invention refers to a process for preparing a compound of the formula (I) wherein R denotes an organic radical which, together with the two carbon atoms to which it is bonded, forms a carbocyclic or heterocyclic ring; R1, R2, R3 and X, independently, denote hydrogen, halogen, nitro, cyano or an organic radical; or R1 and R2 or R2 and R3, together with the carbon atoms to which they are bonded, form a ring; which comprises exposing a compound of the formula (II) wherein R1, R2, R3 and X are defined as given above and Y and Z, independently, have one of the meanings of X; to an energy source in the presence of a catalyst system.

专利号:CN-115043837-A
优先权日:2022-07-18
标 题:Synthesis method and application of 4-imidazopyridinylthioisoquinoline heterocyclic compound