CAS: 31970-04-4; Benzyl 2,5-Dihydro-1H-Pyrrole-1-Carboxylate

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CAS号109-96-6 3-吡咯啉 | CAS号501-53-1 氯甲酸苄酯 | CAS号25070-76-2 N-(benzyloxycar... | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号100858-33-1 (|R|)-(-)-1-Cbz... | CAS号63468-63-3 2,5-二氢吡咯盐酸盐 | CAS号1885-14-9 氯甲酸苯酯 | CAS号95656-88-5 N-Cbz-3-羟基吡咯烷 | CAS号6913-92-4 N-苄基-2,5-二氢吡咯 | CAS号75315-63-8 2,5-二氧代吡咯烷-1-羧酸苄酯 | CAS号95656-88-5 N-Cbz-3-羟基吡咯烷 | CAS号596793-30-5 (3S,4S)-N-Cbz-3... | CAS号131565-87-2 (3S,4R)-吡咯烷-3,4-二醇 | CAS号124391-76-0 (S)-1-Cbz-3-(羟甲基)吡咯烷 | CAS号31865-25-5 3-CBZ-6-氧杂-3-氮杂... | CAS号100858-32-0 (S)-(+)-1-Cbz-3-吡咯烷醇 | CAS号100858-33-1 (|R|)-(-)-1-Cbz... | CAS号134575-15-8 exo-3-[(苄氧基)羰基]... | CAS号68471-57-8 2,3-二氢吡咯-1-羧酸苄酯

Benzyl Diallylcarbamate置于grubbs Catalyst First Generation体系中,用 二氯甲烷 用作溶剂,化学反应 5.0H,以1.031 G的收率获得3-吡咯烷-1-甲酸苄酯
参考文献:3-(3,4,5-三甲氧基苯基)-吡咯烷的合成:一种新的构象限制美斯卡林类似物
标题:3-(3,4,5-三甲氧基苯基)-吡咯烷的合成:一种新的构象限制美斯卡林类似物
摘要:摘要 3-(3,4,5-三甲氧基苯基)-吡咯烷是一种新型的,构象受限的美斯卡林类似物,以简洁有效的方式完成了全合成.合成路线仅包括起始 N-Cbz-3-吡咯烷的 4 个步骤,总产率为 46%.该路线的特点是非活化烯烃 N-Cbz-3-吡咯烷与 3,4,5-三甲氧基苯重氮四氟硼酸盐的高效 Heck 芳基化.半胺醛(内酰胺醇)heck 加合物在一系列反应中转化为美斯卡林类似物:(a)中间体半胺 3 与三氟乙酸酐脱水,(b)内环烯氨基甲酸酯 6 与 H2-Pd/c 的氢化/氢解,和 (C) 形成盐酸盐形式的相当稳定的美斯卡林类似物.
Doi:10.1080/00397910701356504

专利信息

专利号:US-8987504-B2
优先权日:2010-06-18
标题 :Aminohydroxylation of alkenes
发明人：MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL
权利人:MEE SIMON PETER HAROLD; LUXENBURGER ANDREAS; HARRIS LAWRENCE DANIEL; VICTORIA LINK LTD
摘要:The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

专利号:EP-3901145-A1
优先权日:2014-05-13
标题:Deuterated heterocyclic compounds and their use in the synthesis of imaging agents