CAS: 3020-28-8; (Iodomethyl)Triphenylphosphonium Iodide

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📜甲基三苯基碘化膦置于正丁基锂,碘体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应生成 碘甲基-三苯基-碘化磷
参考文献:(-)-Dictyostatin,16-Desmethyl-25,26-Dihydrodictyostatin 和 6-Epi-16-Desmethyl-25,26-Dihydrodictyostatin 的简化合成
标题:(-)-Dictyostatin,16-Desmethyl-25,26-Dihydrodictyostatin 和 6-Epi-16-Desmethyl-25,26-Dihydrodictyostatin 的简化合成
摘要:Dictyostatins 是一类很有前景的潜在抗癌药物,因为它们是强大的微管稳定剂,但其化学结构的复杂性严重阻碍了它们的进一步发展.在合成和药物化学分析的基础上,16-Desmethyl-25,26-Dihydrodictyostatin 及其 C6 差向异构体被选为潜在有效但可用的 Dictyostatin 类似物,并开发了三种新的合成方法.涉及乙烯基锂加成和大环化的相对经典的合成让位于基于酯化和闭环复分解反应的更新和更实用的方法.最后,结合这两种方法的各个方面以提供基于酯化和 Nozaki-Hiyama-Kishi 反应的第三种新合成.这用于制备目标二氢类似物和天然产物.由于它们的高收敛性,所有的合成都是流线型的.这项工作提供了几种新的 Dictyostatin 类似物,包括截短的大环内酯和 C10 E-烯烃,它们的活性分别比 (-)-Dictyostatin 低 400 和 50 倍.相比之下,靶向
DOI:10.1021/ja103537U

专利信息

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:US-7968736-B2
优先权日:2002-09-06
标 题:Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
发明人：CURRAN DENNIS P; SHIN YOUSEUNG; CHOY NAKYEN; DAY BILLY W; BALACHANDRAN RAGHAVAN; MADIRAJU CHARITHA; TURNER TIFFANY
权利人:UNIV PITTSBURGH & MDASH OF THE COMMONWELTH SYSTEMS OF HIGHER EDUCATION
摘要:A compound of the following structure: n n n n n n n n n n wherein R 1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; n R 2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; n R a , R b and R c are independently an alkyl group or an aryl group; n R d is an alkyl group, an aryl group, an alkoxylalkyl group, —R i SiR a R b R c or a benzyl group, wherein R i is an alkylene group; n R e is an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or —NR g R h , wherein R g and R h are independently H, an alkyl group or an aryl group; n R 3 is (CH 2 ) n where n is and integer in the range of 0 to 5, —CH 2 CH(CH 3 )—, —CHâ•?CH—, —CHâ•?C(CH 3 )—, or —C≡C—; n R 4 n n n n n n n n n n n n  wherein y1 and y2 are 1 and y3, y4 and y5 are independently 0 or 1, R k1 , R k2 , R k3 , R k4 and R k5 are independently H, CH 3 , or OR 2a , and R s1 , R s2 , R s3 , and R s4 are independently H or CH 3 , wherein R 2a is H, an alkyl group, an aryl group, a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e ; and n R 5 is H or OR 2b , wherein R 2b is H, an alkyl group, an aryl group, an aryl group,a benzyl group, a trityl group, —SiR a R b R c , CH 2 OR d , or COR e .

专利号:US-11465997-B2
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents
发明人：NICOLAOU KYRIACOS C; BELLAVANCE GABRIEL; BUCHMAN MAREK; PULUKURI KIRAN KUMAR; RIGOL STEPHAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

专利号:WO-2018237178-A1
优先权日:2017-06-22
标题:Synthesis of disorazoles and analogs thereof as potent anticancer agents

专利号:EP-3641891-A1
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents